Inchingolo Angelo Michele, Marinelli Grazia, Trilli Irma, Del Vecchio Gaetano, Di Noia Angela, Inchingolo Francesco, Del Fabbro Massimo, Palermo Andrea, Inchingolo Alessio Danilo, Dipalma Gianna
Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Department of Biomedical, Surgical and Dental Sciences, Milan University, 20122 Milan, Italy.
J Funct Biomater. 2025 Sep 1;16(9):321. doi: 10.3390/jfb16090321.
Bovine bone-derived xenografts are widely used in regenerative dental procedures due to their osteoconductive properties and volumetric stability. However, their long-term behavior and biological integration remain a subject of debate. This systematic review aims to critically assess the histological and clinical outcomes associated with bovine xenografts over extended follow-up periods.
An electronic search was performed in PubMed, Scopus, and Web of Science, including studies published in the English language from 2005 to 2025 for a total of 217 records, which were initially identified from PubMed, Scopus, and Wos.
After duplicate removal, following title/abstract screening and full-text evaluation, 11 studies met the inclusion criteria. These studies reported on the use of bovine-derived xenografts in clinical contexts, assessing parameters such as graft integration, histological remodeling, complication incidence (e.g., chronic inflammation or foreign body reactions), and implant success rates over time.
The current evidence suggests that bovine-derived xenografts, particularly Bio-Oss, are associated with favorable long-term outcomes in bone regenerative procedures, demonstrating satisfactory graft integration and implant survival rates. However, variations in study design, follow-up duration, and outcome measures warrant further high-quality, long-term randomized clinical trials to confirm these findings and guide clinical decision-making.
牛骨来源的异种移植物因其骨传导特性和体积稳定性而广泛应用于牙齿再生手术。然而，它们的长期行为和生物整合情况仍存在争议。本系统评价旨在严格评估长期随访期内与牛异种移植物相关的组织学和临床结果。
在PubMed、Scopus和Web of Science数据库中进行电子检索，纳入2005年至2025年发表的英文研究，共检索到217条记录，最初从PubMed、Scopus和Web of Science数据库中识别得到。
在去除重复记录、进行标题/摘要筛选和全文评估后，有11项研究符合纳入标准。这些研究报告了牛来源异种移植物在临床中的应用情况，评估了移植物整合、组织学重塑、并发症发生率（如慢性炎症或异物反应）以及随时间推移的种植体成功率等参数。
目前的证据表明，牛来源的异种移植物，特别是Bio-Oss，在骨再生手术中具有良好的长期效果，显示出令人满意的移植物整合和种植体存活率。然而，研究设计、随访时间和结果测量方法的差异需要进一步开展高质量、长期的随机临床试验，以证实这些发现并指导临床决策。
