Namiranian Behnam, Doi Kenichiro, Alenezi Salem, Shah Sameer B, Jerban Saeed, Chang Eric Y
Department of Radiology, University of California, San Diego, CA 92093, USA.
Department of Orthopedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka 810-0180, Japan.
Tomography. 2025 Sep 1;11(9):101. doi: 10.3390/tomography11090101.
Micro-computed tomography (micro-CT) is a commonly used tool for bone evaluation in animal model research. Micro-scale finite element analysis (µFEA) has been proposed to account for different loading scenarios, detailed three-dimensional (3D) bone structure, material properties, and distribution obtained from micro-CT to estimate bone mechanical properties and to predict its potential fracture. The in vivo application of µFEA has been limited to animal models due to the smaller bore size of micro-CT and the long scan time. This narrative review article describes studies that used micro-CT-based µFEA to predict bone mechanical competence, understand bone fracture and remodeling mechanisms, and to evaluate the impacts of the therapeutics, implants, and surgical interventions. Moreover, the concept, limitations, and future potentials of micro-CT-based FEA are discussed.
微计算机断层扫描（micro-CT）是动物模型研究中常用的骨评估工具。微尺度有限元分析（µFEA）已被提出，用于考虑不同的加载情况、从微CT获得的详细三维（3D）骨结构、材料特性和分布，以估计骨力学性能并预测其潜在骨折情况。由于微CT孔径较小且扫描时间长，µFEA的体内应用仅限于动物模型。这篇叙述性综述文章描述了使用基于微CT的µFEA来预测骨力学能力、理解骨折和重塑机制以及评估治疗方法、植入物和手术干预影响的研究。此外，还讨论了基于微CT的有限元分析的概念、局限性和未来潜力。
