Gu Yuyang, Li Yanjun, Qian Tingting, Xu Xiaofang
Department of Oncology, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang, People's Republic of China.
Department of Radiology, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, 314000, Zhejiang, People's Republic of China.
Discov Oncol. 2025 Sep 26;16(1):1715. doi: 10.1007/s12672-025-03498-9.
Colon adenocarcinoma (COAD) ranks among the most prevalent malignancies. C-type lectin domain family 11 member A (CLEC11A) plays a role in the initiation and progression of various cancers. However, its involvement in COAD remains unclear. This study reveals that CLEC11A expression is significantly elevated in COAD tissues compared to normal counterparts. Moreover, higher CLEC11A levels correlate with advanced T and N stages as well as pathological stage. Survival analysis further indicates that elevated CLEC11A expression is linked to poor prognosis. Cox regression analysis identifies CLEC11A as an independent prognostic factor for unfavorable survival outcomes. Additionally, increased CLEC11A expression shows a positive association with immune cell infiltration and immune checkpoint markers. CLEC11A-related differentially expressed genes (DEGs) were also identified, and functional enrichment analyses were conducted to elucidate the biological roles of CLEC11A. Unsupervised cluster analysis of these DEGs across distinct subgroups was also performed. In conclusion, CLEC11A has the potential as both a prognostic biomarker and a modulator of immune responses in COAD.
结肠腺癌（COAD）是最常见的恶性肿瘤之一。C型凝集素结构域家族11成员A（CLEC11A）在多种癌症的发生和发展中发挥作用。然而，其在COAD中的作用仍不清楚。本研究表明，与正常组织相比，COAD组织中CLEC11A的表达显著升高。此外，较高的CLEC11A水平与晚期T和N分期以及病理分期相关。生存分析进一步表明，CLEC11A表达升高与预后不良有关。Cox回归分析确定CLEC11A是生存结果不良的独立预后因素。此外，CLEC11A表达增加与免疫细胞浸润和免疫检查点标志物呈正相关。还鉴定了与CLEC11A相关的差异表达基因（DEG），并进行了功能富集分析以阐明CLEC11A的生物学作用。还对这些DEG在不同亚组中进行了无监督聚类分析。总之，CLEC11A有潜力作为COAD的预后生物标志物和免疫反应调节剂。
