Zhu Yan, Chen Qifeng, Huang Mingang, Chen Kangkang
Emergency Internal Medicine, Shaoxing Seventh People's Hospital (Affiliated Mental Health Center, Medical College of Shaoxing University), Shaoxing, China.
Department of Non-communicable Diseases Control and Prevention, Shaoxing Center for Disease Control and Prevention, 276 Century Street, Shaoxing, 312000, Zhejiang Province, China.
Sci Rep. 2025 Sep 26;15(1):33022. doi: 10.1038/s41598-025-18511-y.
a position paper by the Japanese Working Group for Respiratory Sarcopenia (JWGRS). However, the clinical values of probable RS remain unclear. Therefore, we conducted a longitudinal study to determine its impacts on short- and long-term all-cause mortality. Our data were extracted from the China Health and Retirement Longitudinal Study. A total of 5,006 participants were selected as a cohort in 2011, and followed up until 2020. According to the JWGRS, probable RS was defined as a coexistence of low respiratory muscle strength and low appendicular skeletal muscles (ASM) mass. Hazard ratios (HRs) for all-cause mortality and cause-specific mortality were calculated through Cox regression analyses. After an average of 9 years of follow up, 1,176 of the 5,006 participants (23.49%) died. Cox proportional hazard regression showed that low ASM mass (HR = 1.24, 95% CI = 1.09-1.41, P < 0.001), low respiratory muscle strength (HR = 1.31, 95% CI = 1.11-1.54, P = 0.001), and probable RS (HR = 1.31, 95% CI = 1.15-1.48, P < 0.001) were associated with increased all-cause mortality. However, when the follow-up period was shortened to 2 years, the association between probable RS and all-cause mortality became non-significant (P = 0.246), although it remained significant for respiratory-related mortality (HR = 3.16, 95% CI = 1.39-7.18, P = 0.006). Diagnosing probable RS and leading to intervention could significantly prevent and reduce the burden of long-term all-cause mortality.
这是日本呼吸肌减少症工作组（JWGRS）的一篇立场文件。然而，疑似呼吸肌减少症（RS）的临床价值仍不明确。因此，我们进行了一项纵向研究，以确定其对短期和长期全因死亡率的影响。我们的数据来自中国健康与养老追踪调查。2011年共选取5006名参与者作为队列，并随访至2020年。根据JWGRS的标准，疑似RS被定义为呼吸肌力量低和四肢骨骼肌（ASM）质量低同时存在。通过Cox回归分析计算全因死亡率和特定原因死亡率的风险比（HRs）。平均随访9年后，5006名参与者中有1176人（23.49%）死亡。Cox比例风险回归显示，低ASM质量（HR = 1.24，95%CI = 1.09 - 1.41，P < 0.001）、低呼吸肌力量（HR = 1.31，95%CI = 1.11 - 1.54，P = 0.001）和疑似RS（HR = 1.31，95%CI = 1.15 - 1.48，P < 0.001）与全因死亡率增加相关。然而，当随访期缩短至2年时，疑似RS与全因死亡率之间的关联变得不显著（P = 0.246），尽管其与呼吸相关死亡率仍显著相关（HR = 3.16，95%CI = 1.39 - 7.18，P = 0.006）。诊断疑似RS并进行干预可显著预防和减轻长期全因死亡率的负担。
