皮肤界面生物电阻抗测量中的混杂因素及其缓解措施
Confounding Factors and Their Mitigation in Measurements of Bioelectrical Impedance at the Skin Interface.
作者信息
Iftime Adrian, Scheau Cristian, Babeș Ramona-Madalina, Ionescu Diana, Periferakis Argyrios, Călinescu Octavian
机构信息
Department of Biophysics, The "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Bvd., 050474 Bucharest, Romania.
Department of Physiology, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
出版信息
Bioengineering (Basel). 2025 Aug 28;12(9):926. doi: 10.3390/bioengineering12090926.
BACKGROUND
Bioelectrical impedance measurement is a technique used in engineering (development of different wearable biosensors with diverse applications), in the medical field (health monitoring and diagnosis), and in biomedical research (fundamental and applied).
PROBLEM
despite its long history and existence of standardized techniques, measurement results can often be unreliable and plagued by high variance (intra- and inter-subject measurement), which can distort the correct interpretation of the results.
METHODS
we have reviewed bioelectrical impedance measurements from both engineering and medical research teams over the past 60 years, with a focus on factors that might influence the skin-electrode interface.
RESULTS
We identified 40 confounding factors in 10 different categories, some of which are sometimes overlooked in applied research, and we propose mitigation strategies for each one.
背景
生物电阻抗测量是一种应用于工程领域（开发具有多种应用的不同可穿戴生物传感器）、医学领域（健康监测与诊断）以及生物医学研究（基础研究和应用研究）的技术。
问题
尽管其历史悠久且存在标准化技术，但测量结果往往不可靠，并且受高方差（受试者内和受试者间测量）困扰，这可能会歪曲对结果的正确解读。
方法
我们回顾了过去60年工程和医学研究团队的生物电阻抗测量，重点关注可能影响皮肤-电极界面的因素。
结果
我们在10个不同类别中识别出40个混杂因素，其中一些在应用研究中有时被忽视，并且我们为每个因素提出了缓解策略。
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