Utz Sandra, Uecker Christine, Kropač Stefanie, Langhorst Jost
Department for Integrative Medicine, Medical Faculty, University of Duisburg-Essen, 45117 Essen, Germany.
Department of Internal and Integrative Medicine, Sozialstiftung Bamberg, 96049 Bamberg, Germany.
Biomedicines. 2025 Sep 2;13(9):2144. doi: 10.3390/biomedicines13092144.
: The fibromyalgia syndrome (FMS) is classified as a functional somatic syndrome and is characterized primarily by chronic pain in multiple body regions and physical and/or mental fatigue. The German S3-guideline recommends a multimodal therapy for severe forms. Since research on non-pharmacologic complementary, naturopathic, and integrative therapy approaches shows positive and promising effects, integrative methods are firmly anchored in the S3 guideline. : Aim of the present study was to investigate whether a multimodal integrative treatment program can be effective in reducing the primary symptoms of FMS (pain and fatigue) and improving psychological aspects such as quality of life (QoL), anxiety, depression, and perceived stress. Another aim of the study is to explore whether potential effects appear only in the short term (immediately after discharge) or persist long term (six months after discharge). The treatment concept is based on mind-body medicine and elements of classical European naturopathy (including fasting interventions) and focusses on stress reduction and lifestyle modification. : Of N = 134 originally included longstanding fibromyalgia patients (mean time since diagnosis 9.2 ± 8.5 years), 101 data sets could be analyzed. Results show a significant improvement in both short-term and long-term pain and fatigue intensity (about 12% improvement). Long-term reductions in pain intensity appear to be supported by medical fasting interventions. Regarding psychological aspects and quality of life, there are long-lasting reductions regarding anxiety, depression, perceived stress, and helplessness and a long-lasting increase in self-efficacy, quality of life and current working ability. : The two-weeks inpatient stay therefore leads to significant improvements in all mentioned aspects. Therefore, the concept may be a promising component for integration into medical guidelines and thus in the care of FMS patients. Future research including randomized controlled trials is necessary to further evaluate the program.
纤维肌痛综合征（FMS）被归类为功能性躯体综合征，其主要特征是身体多个部位的慢性疼痛以及身体和/或精神疲劳。德国S3指南推荐对严重形式采用多模式疗法。由于对非药物补充、自然疗法和综合治疗方法的研究显示出积极且有前景的效果，综合方法已牢固地纳入S3指南。：本研究的目的是调查多模式综合治疗方案是否能有效减轻FMS的主要症状（疼痛和疲劳），并改善心理方面，如生活质量（QoL）、焦虑、抑郁和感知压力。该研究的另一个目的是探索潜在效果是仅在短期（出院后立即）出现还是长期（出院后六个月）持续存在。治疗理念基于身心医学和经典欧洲自然疗法的要素（包括禁食干预），并侧重于减轻压力和改变生活方式。：最初纳入的N = 134例长期纤维肌痛患者（自诊断以来的平均时间为9.2±8.5年）中，有101个数据集可供分析。结果显示，短期和长期的疼痛和疲劳强度均有显著改善（改善约12%）。医学禁食干预似乎有助于长期减轻疼痛强度。在心理方面和生活质量方面，焦虑、抑郁、感知压力和无助感有长期减轻，自我效能感、生活质量和当前工作能力有长期提高。：因此，两周的住院治疗在所有上述方面都带来了显著改善。因此，该理念可能是纳入医学指南并从而用于FMS患者护理的一个有前景的组成部分。未来需要包括随机对照试验在内的研究来进一步评估该方案。
