Mehler Isabella Silke Elisabeth, Heinrich Sven Pascal, Böhringer Daniel, Simon Valentin, Bleul Tim, Küchlin Sebastian, Lagrèze Wolf Alexander, Farassat Navid
Eye Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Baden-Württemberg, 79106 Freiburg, Germany.
Life (Basel). 2025 Sep 1;15(9):1384. doi: 10.3390/life15091384.
Blue-light stimulation of the optic disc has been suggested as a means of myopia prevention by activating dopaminergic amacrine cells via intrinsically photosensitive retinal ganglion cells. This prospective, adequately powered study investigated this approach by examining its effects on pattern electroretinogram (PERG) N95 amplitude and choroidal thickness (ChT), established biomarkers associated with retinal ganglion cell function and myopia progression, respectively. Forty-six healthy adults received one minute of 450 nm blue-light stimulation to either the optic disc or central retina of the right eye, with the fellow left eye serving as control. PERG responses were measured before and 20 min after stimulation (N = 15 per stimulation location), while ChT, using swept-source optical coherence tomography images, was measured before, 20, and 60 min after stimulation (N = 8 per stimulation location). Only retinal stimulation significantly increased PERG N95 amplitude (baseline 16.16 µV, post-stimulation 17.61 µV [ = 0.01]), whereas optic disc stimulation did not (baseline 18.71 µV, post-stimulation 18.81 µV [ = 0.76]). Neither optic disc nor retinal stimulation significantly changed ChT at any time point. No significant differences were observed between myopic and non-myopic participants. Our findings do not support the hypothesis that short-duration blue-light stimulation of the optic disc is a viable strategy to activate retinal dopaminergic pathways for myopia prevention.
通过内在光敏性视网膜神经节细胞激活多巴胺能无长突细胞，蓝光刺激视盘已被提议作为一种预防近视的方法。这项前瞻性、有足够样本量的研究通过检查其对图形视网膜电图（PERG）N95波幅和脉络膜厚度（ChT）的影响来研究这种方法，这两个指标分别是与视网膜神经节细胞功能和近视进展相关的既定生物标志物。46名健康成年人接受了1分钟450纳米蓝光对右眼视盘或中央视网膜的刺激，左眼作为对照。在刺激前和刺激后20分钟测量PERG反应（每个刺激部位n = 15），同时使用扫频光学相干断层扫描图像在刺激前、刺激后20分钟和60分钟测量ChT（每个刺激部位n = 8）。只有视网膜刺激显著增加了PERG N95波幅（基线16.16微伏，刺激后17.61微伏[ = 0.01]），而视盘刺激没有（基线18.71微伏，刺激后18.81微伏[ = 0.76]）。视盘刺激和视网膜刺激在任何时间点均未显著改变ChT。近视参与者和非近视参与者之间未观察到显著差异。我们的研究结果不支持以下假设：对视盘进行短时间蓝光刺激是激活视网膜多巴胺能通路以预防近视的可行策略。
