Brockhausen Inka
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Molecules. 2025 Sep 14;30(18):3735. doi: 10.3390/molecules30183735.
Hans Paulsen was one of the first scientists who believed that chemistry should be applied to biology and medicine. His interest in natural products and their roles solidified in the 1970s. He passed on his knowledge to hundreds of students and coworkers and advanced science with many national and international collaborators. No matter where he was, at home or travelling, he was always curious and keen to learn, from chemistry to enzymes, their roles in diseases, and the possible applications of synthetic compounds. His creative chemistry and synthesis of novel compounds made essential contributions to elucidating the mechanisms and pathways of glycoprotein biosynthesis. This review describes the biosynthetic pathways of the O- and N-glycans of glycoproteins and studies of novel substrates and inhibitors developed by Hans Paulsen's group.
汉斯·保尔森是最早一批认为化学应应用于生物学和医学的科学家之一。他对天然产物及其作用的兴趣在20世纪70年代得以巩固。他将自己的知识传授给了数百名学生和同事，并与许多国内外合作者共同推动了科学发展。无论他身处家中还是旅行途中，他总是充满好奇心，渴望学习，从化学到酶、它们在疾病中的作用以及合成化合物的可能应用。他富有创造性的化学研究和新型化合物的合成，为阐明糖蛋白生物合成的机制和途径做出了重要贡献。本综述描述了糖蛋白O-聚糖和N-聚糖的生物合成途径，以及汉斯·保尔森团队开发的新型底物和抑制剂的研究情况。
