（）作为抗病毒药物的新来源：其生物活性植物化学物质和给药途径概述

() as a Novel Source of Antiviral Agents: Overview of Its Bioactive Phytochemicals and Delivery Approaches.

作者信息

Dahan Arik, Yarmolinsky Ludmila, Nakonechny Faina, Semenova Olga, Khalfin Boris, Fleisher-Berkovich Sigal, Ben-Shabat Shimon

机构信息

Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

Department of Chemical Engineering, Ariel University, Ariel 4070000, Israel.

出版信息

Pharmaceutics. 2025 Sep 9;17(9):1173. doi: 10.3390/pharmaceutics17091173.

DOI:10.3390/pharmaceutics17091173

PMID:41012509

Abstract

The recent COVID-19 pandemic highlighted the significant challenge of insufficient antiviral pharmacological options. Edible plants offer a promising avenue for developing novel antiviral drugs. Etrog citron ( L.), which is a valuable edible and medicinal plant, contains various antiviral phytochemicals, mainly flavonoids, coumarins, and terpenes. However, the therapeutic application of these compounds remains limited by factors such as poor solubility, limited bioavailability, and unclear mechanisms of action. The aim of the present article is to offer a comprehensive analysis of the antiviral phytochemicals extracted from various parts of , emphasizing their mode of action and delivery strategies that may allow turning these compounds into new antiviral drugs.

摘要

最近的新冠疫情凸显了抗病毒药物选择不足这一重大挑战。可食用植物为开发新型抗病毒药物提供了一条有前景的途径。香橼（Citrus medica L.）是一种珍贵的可食用和药用植物，含有多种抗病毒植物化学物质，主要是黄酮类、香豆素类和萜类。然而，这些化合物的治疗应用仍然受到溶解度差、生物利用度有限以及作用机制不明确等因素的限制。本文的目的是全面分析从香橼各部位提取的抗病毒植物化学物质，强调它们的作用方式以及可能使这些化合物转化为新型抗病毒药物的递送策略。