Decabooter Gautier, Verso Luca Lo, Guay Frederic, Filteau Marie, Fliss Ismail
Departement des Sciences des Aliments, Faculte des Sciences de l'Agriculture Et de l'Alimentation (FSAA), Universite Laval, Quebec, QC, G1V 0A6, Canada.
Institut Sur La Nutrition Et Les Aliments Fonctionnels (INAF), Quebec, QC, G1V 0A6, Canada.
Curr Microbiol. 2025 Sep 27;82(11):530. doi: 10.1007/s00284-025-04514-5.
Post-weaning piglets often face digestive challenges and growth setbacks due to gut microbiota imbalances and increased susceptibility to infections and diarrhea. Various alternatives to antibiotic growth promoters have been proposed, including synbiotic supplements. Maple syrup is a source of prebiotic compounds, while Bacillus velezensis FZB42 is a nonpathogenic microorganism with probiotic potential. Therefore, this study investigated the effects of a fermented ingredient combining maple syrup and B. velezensis as a potential synbiotic. The focus was on growth performance, occurrence of diarrhea, short-chain fatty acid production, and intestinal microbiota composition in weaned piglets. A two-week experiment in a randomized complete block design was conducted with the following treatments: a negative control diet (NC); a positive control diet containing chlortetracycline hydrochloride (PC); a synbiotic supplement containing maple syrup and B. velezensis (SYN); and a freeze-dried maple syrup supplement (FMS). Compared to the NC group, SYN supplementation increased final body weight, average daily gain, and decreased the feed conversion ratio (p < 0.05). The results showed that dietary supplementation with SYN supplement increased butyric acid concentrations in the ileum compared to NC (p < 0.014) and increased acetic (p < 0.001) and butyric acids (p < 0.044) in the colon compared to PC treatment. Additionally, both maple syrup-based supplements favorably modulated the relative abundance of microbial taxa, increasing Oscillisibacter and reducing Campylobacter, among others. Our findings indicate that dietary supplementation with a synbiotic composed of B. velezensis FZB42 and maple syrup improved the growth performance of weanling piglets, increased acetic and butyric acid content in the colon and butyric acid in the ileum, and favorably modulated the intestinal microbiota.
断奶仔猪由于肠道微生物群失衡以及对感染和腹泻的易感性增加，常常面临消化挑战和生长挫折。人们已经提出了各种抗生素生长促进剂的替代品，包括合生元补充剂。枫糖浆是益生元化合物的来源，而贝莱斯芽孢杆菌FZB42是一种具有益生菌潜力的非致病微生物。因此，本研究调查了将枫糖浆和贝莱斯芽孢杆菌作为潜在合生元的发酵成分的效果。重点是断奶仔猪的生长性能、腹泻发生率、短链脂肪酸产生以及肠道微生物群组成。采用随机完全区组设计进行了为期两周的实验，设置以下处理：阴性对照日粮（NC）；含盐酸金霉素的阳性对照日粮（PC）；含枫糖浆和贝莱斯芽孢杆菌的合生元补充剂（SYN）；以及冻干枫糖浆补充剂（FMS）。与NC组相比，补充SYN提高了末体重、平均日增重，并降低了饲料转化率（p < 0.05）。结果表明，与NC相比，日粮中添加SYN补充剂可提高回肠中丁酸浓度（p < 0.014），与PC处理相比，可提高结肠中乙酸（p < 0.001）和丁酸（p < 0.044）浓度。此外，两种基于枫糖浆的补充剂均对微生物类群的相对丰度产生了有利调节作用，增加了颤螺菌属并减少了弯曲杆菌属等。我们的研究结果表明，日粮中添加由贝莱斯芽孢杆菌FZB42和枫糖浆组成的合生元可改善断奶仔猪的生长性能，增加结肠中乙酸和丁酸含量以及回肠中丁酸含量，并对肠道微生物群产生有利调节作用。
