Rofstad E K, Brustad T, Kaalhus O
Virchows Arch B Cell Pathol. 1977 Aug 10;24(3):219-25. doi: 10.1007/BF02889281.
The technique of labelled mitoses was used to investigate the cell proliferation kinetics in two human neoplasms, one a malignant melanoma and one a fibrosarcoma, transplanted to and grown serially in the athymic nude mutant (ANM) mouse. The experimental data obtained codrealted well with a theoretical percentage labelled mitoses curve based on the assumption that the time spent by a cell in each of the phases M, G1, S and G2 is described by four independent log-normal distributions. However, no unique second wave was defined by the experimental results. This means that only the deductions made about the duration of the G2 and S phases are reliable. The median duration of tma and the fibrosarcoma, respectively. By comparing these results with results published on cell cycle studies of transplantable animal tumors and human tumors in situ, it is concluded that the cell cycle parameters of a human tumor grown in the ANM mouse are close to those of the same tumor in the donor patient.
采用标记有丝分裂技术研究了两种人类肿瘤的细胞增殖动力学，一种是恶性黑色素瘤，另一种是纤维肉瘤，它们被移植到无胸腺裸突变（ANM）小鼠体内并连续传代生长。基于细胞在M期、G1期、S期和G2期各阶段所花费时间由四个独立对数正态分布描述的假设，获得的实验数据与理论标记有丝分裂百分比曲线相关性良好。然而，实验结果并未定义出独特的第二波。这意味着仅关于G2期和S期持续时间的推断是可靠的。分别是tma和纤维肉瘤的中位持续时间。通过将这些结果与已发表的关于可移植动物肿瘤和原位人类肿瘤细胞周期研究的结果进行比较，得出在ANM小鼠体内生长的人类肿瘤的细胞周期参数与供体患者体内相同肿瘤的细胞周期参数相近的结论。
