Mohan Falah Jaber, Taher Hanan J, Jasim Ali Aseel
Institute of Laser for Postgraduate, University of Baghdad, Baghdad, Iraq.
Department of Dentistry, Al-Mansour University College, Baghdad, Iraq.
Lasers Med Sci. 2025 Sep 29;40(1):391. doi: 10.1007/s10103-025-04596-4.
Photobiomodulation therapy (PBMT), which involves both stimulatory and inhibitory biological responses to light, represents a critical area of research requiring further in-depth exploration. This study aimed to evaluate and compare the effects of 650 nm and 450 nm diode lasers on wound healing following tooth extraction in a rabbit model. Local anesthesia was used. A continuous-wave (CW) diode laser with wavelengths of 650 then 450 were used on wound after tooth extraction in 30 rabbits divided into three groups randomly and equally separated groups: control group (G1), 650 nm group (G2) and 450 nm group (G3), with laser parameters determined based on a prior pilot study in rabbits. The energy density for a 30-second exposure was 7.64 J/cm². The power output and the power density were 200 mW and 254 mW per cm, respectively. By day 7, 70% of rabbits in the G2 exhibited pink gingival tissue, compared to only 40% in the G3.Healing outcomes demonstrated statistically significant (p < 0.05) in G2in the gingival color and thickness relative to those G1 and G3.By day 14, none of theG1 displayed severe congestion, whereas G2 showed normal tissue recovery without pathological secretion(only two rabbits in G3 showed suppuration).Histopathological analysis revealed that 650 nm PBMT stimulated partial epithelialization and collagen deposition by day 7, with further enhancement by day 14. The 650 nm wavelength demonstrated superior healing effects, characterized by increased pink gingival tissue, reduced bleeding, and absence of inflammation. Photobiomodulation therapy (PBM) accelerates wound healing and is effective in reducing inflammation. Further research is needed to optimize wavelength selection.Clinical trial number Not applicable.
光生物调节疗法（PBMT）涉及对光的刺激和抑制生物反应，是一个需要进一步深入探索的关键研究领域。本研究旨在评估和比较650nm和450nm二极管激光对兔模型拔牙后伤口愈合的影响。采用局部麻醉。将30只兔子随机等分为三组：对照组（G1）、650nm组（G2）和450nm组（G3），拔牙后对伤口使用波长为650nm然后450nm的连续波（CW）二极管激光，激光参数根据之前对兔子的预试验确定。30秒照射的能量密度为7.64J/cm²。功率输出和功率密度分别为200mW和每厘米254mW。到第7天，G2组70%的兔子牙龈组织呈粉红色，而G3组只有40%。相对于G1组和G3组，G2组的愈合结果在牙龈颜色和厚度方面具有统计学意义（p＜0.05）。到第14天，G1组均未出现严重充血，而G2组显示组织正常恢复，无病理性分泌物（G3组只有两只兔子出现化脓）。组织病理学分析显示，650nm的PBMT在第7天刺激了部分上皮化和胶原蛋白沉积，到第14天进一步增强。650nm波长显示出更好的愈合效果，表现为粉红色牙龈组织增加、出血减少和无炎症。光生物调节疗法（PBM）可加速伤口愈合并有效减轻炎症。需要进一步研究以优化波长选择。临床试验编号不适用。
