• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于小动物模型疾病建模和治疗应用的体外器官灌注系统

Ex Vivo Organ Perfusion Systems for Disease Modeling and Therapeutic Applications in Small Animal Models.

作者信息

Yeganeh Mina, Zito Andea, Sadat Marwa, Pierro Agostino, Rogers Ian M

机构信息

Translational Medicine Program, Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

出版信息

J Tissue Eng Regen Med. 2025 Sep 18;2025:2583925. doi: 10.1155/term/2583925. eCollection 2025.

DOI:10.1155/term/2583925
PMID:41018117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12463510/
Abstract

Ex vivo organ perfusion (EVOP) is used for whole organ preservation, and the main focus is to improve the outcome of donor organs for transplantation. Recently, EVOP has found application in disease modeling, drug development, and tissue regeneration. We discuss progress in EVOP research involving small animal organs using benchtop and incubator-based EVOP systems, highlighting innovative designs of EVOP systems, technical specifications of each system, and their versatile applications across a range of research fields.

摘要

体外器官灌注（EVOP）用于全器官保存，主要重点是改善供体器官移植的结果。最近，EVOP已在疾病建模、药物开发和组织再生中得到应用。我们讨论了使用基于台式和培养箱的EVOP系统对小动物器官进行的EVOP研究进展，重点介绍了EVOP系统的创新设计、每个系统的技术规格及其在一系列研究领域中的广泛应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/12463510/070337f12a0e/JTERM2025-2583925.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/12463510/6fa0864ac452/JTERM2025-2583925.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/12463510/f0faf084cb4d/JTERM2025-2583925.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/12463510/62566abfbd50/JTERM2025-2583925.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/12463510/070337f12a0e/JTERM2025-2583925.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/12463510/6fa0864ac452/JTERM2025-2583925.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/12463510/f0faf084cb4d/JTERM2025-2583925.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/12463510/62566abfbd50/JTERM2025-2583925.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7da/12463510/070337f12a0e/JTERM2025-2583925.004.jpg

相似文献

1
Ex Vivo Organ Perfusion Systems for Disease Modeling and Therapeutic Applications in Small Animal Models.用于小动物模型疾病建模和治疗应用的体外器官灌注系统
J Tissue Eng Regen Med. 2025 Sep 18;2025:2583925. doi: 10.1155/term/2583925. eCollection 2025.
2
Normothermic and hypothermic machine perfusion preservation versus static cold storage for deceased donor kidney transplantation.常温及低温机器灌注保存与静态冷藏在尸体供肾移植中的比较。
Cochrane Database Syst Rev. 2024 Jul 9;7(7):CD011671. doi: 10.1002/14651858.CD011671.pub3.
3
Contrast-enhanced computed tomography for ex vivo assessment of human kidneys: A proof-of-concept study.对比增强计算机断层扫描在人肾离体评估中的应用：概念验证研究。
Artif Organs. 2024 Dec;48(12):1536-1548. doi: 10.1111/aor.14840. Epub 2024 Aug 27.
4
Assessing the degree of hepatic ischemia-reperfusion injury using physiologically based pharmacokinetic modeling of sodium fluorescein disposition in ex vivo machine-perfused livers.使用生理基础药代动力学模型评估离体机器灌注肝脏中钠荧光素处置的肝缺血再灌注损伤程度。
Am J Physiol Gastrointest Liver Physiol. 2024 Sep 1;327(3):G424-G437. doi: 10.1152/ajpgi.00048.2024. Epub 2024 Jun 25.
5
Expanding the Use of Ex Situ Organ Machine Perfusion Beyond Transplantation.拓展离体器官机器灌注在移植以外领域的应用
Artif Organs. 2025 Aug;49(8):1229-1235. doi: 10.1111/aor.15011. Epub 2025 Apr 22.
6
Heart Perfusion Machines in DCD Heart Transplantation Model: The State of Art.心脏死亡器官捐献心脏移植模型中的心脏灌注机器：现状
Transpl Int. 2025 Aug 13;38:12987. doi: 10.3389/ti.2025.12987. eCollection 2025.
7
The 2024 American Association for Thoracic Surgery expert consensus document: Current standards in donor lung procurement and preservation.《2024年美国胸外科协会专家共识文件：供体肺获取与保存的当前标准》
J Thorac Cardiovasc Surg. 2025 Feb;169(2):484-504. doi: 10.1016/j.jtcvs.2024.08.052.
8
Innovative approaches to organ preservation in heart transplantation: A comprehensive review by the French Society of Thoracic and Cardiovascular Surgery.心脏移植中器官保存的创新方法：法国胸心血管外科学会的综合综述
Arch Cardiovasc Dis. 2025 Sep;118(8-9):489-496. doi: 10.1016/j.acvd.2025.03.119. Epub 2025 Apr 9.
9
A meta-analysis of perfusion parameters affecting weight gain in ex vivo perfusion.一项关于影响离体灌注中体重增加的灌注参数的荟萃分析。
Artif Organs. 2025 Jan;49(1):7-20. doi: 10.1111/aor.14841. Epub 2024 Aug 19.
10
Cost effectiveness of commercial portable ex vivo lung perfusion at a low-volume US lung transplant center.商业便携式体外肺灌注在低容量美国肺移植中心的成本效益。
Artif Organs. 2024 Nov;48(11):1288-1296. doi: 10.1111/aor.14816. Epub 2024 Jun 24.

本文引用的文献

1
Low-Volume Lung Perfusion System for Single Lung Application in a Small Animal Model Enables Optimal Compliance With "" in 3R Principles of Animal Research.小动物模型中单肺应用的低容量肺灌注系统可满足“3R 原则”中动物研究的最佳顺应性。
Transpl Int. 2024 Sep 9;37:13189. doi: 10.3389/ti.2024.13189. eCollection 2024.
2
History of the development of isolated heart perfusion experimental model and its pioneering role in understanding heart physiology.离体心脏灌注实验模型的发展历程及其在理解心脏生理学方面的开创性作用。
Arch Med Sci Atheroscler Dis. 2024 May 29;9:e109-e121. doi: 10.5114/amsad/188270. eCollection 2024.
3
Breaking the limits of experimental pancreas transplantation: Working toward the clinical ideal graft.
突破实验性胰腺移植的局限：朝着临床理想移植物迈进。
Front Transplant. 2022 Oct 21;1:1035480. doi: 10.3389/frtra.2022.1035480. eCollection 2022.
4
Use of the CytoSorb adsorber in patients with acute-on-chronic liver failure.细胞吸附剂 CytoSorb 在慢加急性肝衰竭患者中的应用。
Sci Rep. 2024 May 17;14(1):11309. doi: 10.1038/s41598-024-61658-3.
5
Pushing the boundaries of innovation: the potential of organ perfusion from an interdisciplinary point of view.突破创新界限：跨学科视角下的器官灌注潜力
Front Cardiovasc Med. 2023 Oct 12;10:1272945. doi: 10.3389/fcvm.2023.1272945. eCollection 2023.
6
Normothermic Machine Perfusion of Discarded Human Pancreas Allografts: A Feasibility Study.废弃人胰腺同种异体的常温机器灌注：一项可行性研究。
Transpl Int. 2023 May 11;36:10936. doi: 10.3389/ti.2023.10936. eCollection 2023.
7
Sterile Pancreas Inflammation during Preservation and after Transplantation.移植保存过程中无菌胰腺炎症。
Int J Mol Sci. 2023 Feb 27;24(5):4636. doi: 10.3390/ijms24054636.
8
Evaluating cell viability, capillary perfusion, and collateral tortuosity in an ex vivo mouse intestine fluidics model.在离体小鼠肠道流体模型中评估细胞活力、毛细血管灌注和侧支迂曲度。
Front Bioeng Biotechnol. 2022 Dec 9;10:1008481. doi: 10.3389/fbioe.2022.1008481. eCollection 2022.
9
Technique for xenogeneic cross-circulation to support human donor lungs ex vivo.异种交叉循环技术支持人供肺的体外保存。
J Heart Lung Transplant. 2023 Mar;42(3):335-344. doi: 10.1016/j.healun.2022.11.002. Epub 2022 Nov 14.
10
Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Pancreas Allografts before Transplantation.常温体外胰腺灌注在移植前保存胰腺供体。
J Vis Exp. 2022 Jul 27(185). doi: 10.3791/63905.