用于小动物模型疾病建模和治疗应用的体外器官灌注系统

Yeganeh Mina, Zito Andea, Sadat Marwa, Pierro Agostino, Rogers Ian M

Translational Medicine Program, Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

J Tissue Eng Regen Med. 2025 Sep 18;2025:2583925. doi: 10.1155/term/2583925. eCollection 2025.

Ex vivo organ perfusion (EVOP) is used for whole organ preservation, and the main focus is to improve the outcome of donor organs for transplantation. Recently, EVOP has found application in disease modeling, drug development, and tissue regeneration. We discuss progress in EVOP research involving small animal organs using benchtop and incubator-based EVOP systems, highlighting innovative designs of EVOP systems, technical specifications of each system, and their versatile applications across a range of research fields.

体外器官灌注（EVOP）用于全器官保存，主要重点是改善供体器官移植的结果。最近，EVOP已在疾病建模、药物开发和组织再生中得到应用。我们讨论了使用基于台式和培养箱的EVOP系统对小动物器官进行的EVOP研究进展，重点介绍了EVOP系统的创新设计、每个系统的技术规格及其在一系列研究领域中的广泛应用。