Kim Hyeonji, Ngo Gia-Han, Hong Wen, Lee Soo Hyeon, Mahajan Vinit B, DeBoer Charles
Department of Ophthalmology, School of Medicine, Byers Eye Institute at Stanford University, Palo Alto, CA 94304 USA.
Molecular Surgery Laboratory, Stanford University, Palo Alto, CA 94304 USA.
Curr Ophthalmol Rep. 2025;13(1):10. doi: 10.1007/s40135-025-00337-6. Epub 2025 Sep 26.
In this article, we provide a brief overview of 3D bioprinting technologies and the types of cells employed in ophthalmic cell therapy. We then explore recent applications of 3D bioprinting in ophthalmic cell delivery systems.
Cell therapy in ophthalmology is a promising treatment for various eye diseases, there exists some limitations of existing cell therapy strategies Such as cell loss, poor integration with Surrounding tissues, and the sustainability of long-term effects. In this regard, 3D bioprinting technology provides a beneficial method for developing highly biomimetic and reliable cell delivery systems for ophthalmic disease research. Recent advances have shown bioengineered tissues which replicate the microstructure of native tissues, personalized ophthalmic devices, and encapsulated cell-delivery systems. While still in the early stages of advancement, the development of cell delivery systems based on bioprinting technologies is indeed inspiring and has the potential to be applied to other ocular diseases.
Cell therapy based on 3D bioprinting technology in ophthalmology has great potential in ophthalmic disease treatment as well as ocular tissue engineering and regenerative medicine.
在本文中，我们简要概述了3D生物打印技术以及眼科细胞治疗中使用的细胞类型。然后，我们探讨了3D生物打印在眼科细胞递送系统中的最新应用。
眼科细胞治疗是治疗各种眼部疾病的一种有前景的疗法，但现有细胞治疗策略存在一些局限性，如细胞损失、与周围组织整合不良以及长期效果的可持续性。在这方面，3D生物打印技术为开发用于眼科疾病研究的高度仿生且可靠的细胞递送系统提供了一种有益的方法。最近的进展展示了复制天然组织微观结构的生物工程组织、个性化眼科装置以及封装细胞递送系统。虽然仍处于发展初期，但基于生物打印技术的细胞递送系统的发展确实令人鼓舞，并且有可能应用于其他眼部疾病。
基于3D生物打印技术的眼科细胞治疗在眼科疾病治疗以及眼组织工程和再生医学方面具有巨大潜力。
