多环烃K区域衍生物对啮齿动物细胞的体外转化
In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons.
作者信息
Grover P L, Sims P, Huberman E, Marquardt H, Kuroki T, Heidelberger C
出版信息
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1098-101. doi: 10.1073/pnas.68.6.1098.
Abstract
The K-region epoxides and cis-dihydrodiols derived from benz(a)anthracene and from dibenz(a,h)-anthracene have been found to be more active in the production of malignant transformation in hamster embryo cells than the hydrocarbons or the corresponding K-region phenols. The K-region epoxides derived from benz(a)-anthracene and from 3-methylcholanthrene were also active in transforming a clone of ventral prostate cells from the C3H mouse that was not readily transformed by the parent hydrocarbons. The phenols were the most toxic compounds tested but did not transform cells; this confirms that toxicity and transformation are not directly related events. The results obtained support the view that metabolism of polycyclic hydrocarbons precedes toxicity and transformation in rodent cells in culture.
摘要
已发现，源自苯并(a)蒽和二苯并(a,h)蒽的K区域环氧化物和顺式二氢二醇在仓鼠胚胎细胞中产生恶性转化方面比碳氢化合物或相应的K区域酚更具活性。源自苯并(a)蒽和3-甲基胆蒽的K区域环氧化物在转化C3H小鼠腹侧前列腺细胞克隆时也具有活性，而亲本碳氢化合物不容易转化该克隆。酚是所测试的毒性最大的化合物，但不会转化细胞；这证实了毒性和转化并非直接相关事件。所获得的结果支持这样一种观点，即在培养的啮齿动物细胞中，多环碳氢化合物的代谢先于毒性和转化。
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