Taussig M J, Lachmann P J
Immunology. 1972 Feb;22(2):185-97.
Antigenic competition between the Fc and Fab fragments of rabbit IgG in mice could be abolished by passive immunization with antiserum against the dominant antigen (Fc). The induction of tolerance to Fc also eliminated antigenic competition. Anti-Fd production, generally very poor in response to rabbit IgG, was considerably enhanced by these procedures, indicating that it is also subject to antigenic competition with Fc. A model is proposed to explain antigenic competition which proposes that it is the `co-operative antibody' produced to the dominant antigen which acts as an inhibitor to antibody production to the suppressed antigen by competing for sites —presumably on macrophage membranes—where co-operation occurs. The merits and difficulties of such an explanation are discussed.
兔IgG的Fc和Fab片段在小鼠体内的抗原竞争可通过用针对显性抗原（Fc）的抗血清进行被动免疫来消除。对Fc耐受性的诱导也消除了抗原竞争。通常对兔IgG反应很差的抗Fd产生，通过这些程序得到了显著增强，这表明它也受到与Fc的抗原竞争的影响。提出了一个模型来解释抗原竞争，该模型认为，针对显性抗原产生的“协同抗体”通过竞争——可能是巨噬细胞膜上发生协同作用的位点——来抑制针对被抑制抗原的抗体产生。讨论了这种解释的优点和困难。
