抗原竞争研究。3. 抗原竞争对抗体亲和力的影响。
Studies on antigenic competition. 3. Effect on antigenic competition on antibody affinity.
作者信息
Kim Y T, Merrifield N, Zarchy T, Brody N I, Siskind G W
出版信息
Immunology. 1974 May;26(5):943-55.
Abstract
The effect of antigenic competition on antibody affinity was studied using a haptenic system in guinea-pigs. A moderate depression in the amount of antibody formed, as a result of antigenic competition, had relatively little effect on affinity. Increasing the dose of the competing antigen resulted in a greater degree of competition. Under these conditions a large amount of low affinity antibody was produced by the animals while essentially no high affinity antibody was detectable. Thus, marked competition appeared to result in a failure to select for high affinity antibody synthesis.
摘要
利用豚鼠的半抗原系统研究了抗原竞争对抗体亲和力的影响。由于抗原竞争，所形成的抗体量出现适度下降，这对亲和力的影响相对较小。增加竞争抗原的剂量会导致更大程度的竞争。在这些条件下，动物产生了大量低亲和力抗体，而基本上检测不到高亲和力抗体。因此，明显的竞争似乎导致无法选择高亲和力抗体进行合成。
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