Sýkora I
Vet Med (Praha). 1977 Jun;22(6):377-84.
The stimulative effect of Carbadox, Nitrovin and Glypondin substances was tested on juvenile rats. A stimulative effect relative to physical weight was proved only with Carbadox at a dose of 2 mg kg-1 and Nitrovin (only in males) in doses of 10 and 50 mg kg-1 p. o. An overdosing of Carbadox revealed rather a negative effect, because already a dose ten times higher had a negative effect on physical growth and a dose fifty times higher caused obvious toxical symptoms. Glypondin was ineffective in each of the tested doses. The consumption of food per unit of weight increase was reduced after supplying carbadox dosed at 2 mg kg-1 by 25.6% in males and by 10.8% in females. After Nitrovin the intake of food was reduced most after a dose of 10 mg kg-1 in both sexes (8.6 and 8.4% respectively). The most frequent effect on the change of physical weight was the relative reduction in weight of the thyroid gland. For the screening of stimulators laboratory rats are not very suitable.
在幼鼠身上测试了卡巴多司、硝呋烯腙和甘磷酰芥物质的刺激作用。仅在卡巴多司剂量为2毫克/千克和硝呋烯腙（仅在雄性中）剂量为10和50毫克/千克口服时，证明了相对于体重的刺激作用。卡巴多司过量显示出相当负面的影响，因为剂量高出十倍就对身体生长有负面影响，而高出五十倍的剂量会引起明显的中毒症状。甘磷酰芥在每个测试剂量下均无效。给予2毫克/千克剂量的卡巴多司后，雄性每单位体重增加的食物消耗量减少了25.6%，雌性减少了10.8%。给予硝呋烯腙后，两性在10毫克/千克剂量后食物摄入量减少最多（分别为8.6%和8.4%）。对体重变化最常见的影响是甲状腺重量相对减轻。对于刺激剂的筛选，实验室大鼠不太合适。
