Zhang Meiting, Xu Haocheng, Zhang Tianfeng, Kang Jia, Xu Zhihao, Wu Peng, Niu Yu, Shi Yonghao, Zhong Yifan, Yang Caimei
College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang Agricultural and Forestry University, Hangzhou 311300, China.
Animals (Basel). 2025 Oct 14;15(20):2971. doi: 10.3390/ani15202971.
In recent years, as the number of cats has increased, the intestinal health of cats has receied increasing amounts of attention. Probiotics have positive effects on maintaining intestinal homeostasis. This study was conducted to investigate the effects of probiotics () and () on cat immunity, inflammation, antioxidants, intestinal barrier and microbiota, and serum metabolites. Thirty-six cats (over one year old, 3.48 ± 0.71 kg) were randomly divided into 3 groups and fed with a basal diet (CON group), a basal diet + (BL group), and a basal diet + (BS Group). The experiment lasted 35 days. Fecal scoring indicates that and can improve fecal scores. Serum analysis indicated that the addition of both substances increased levels of IgA, IgM, T-AOC, and SOD, while reducing levels of the pro-inflammatory factor TNF-α. Moreover, 16S rRNA gene sequencing revealed that and altered the fecal microbiota composition, characterized by the elevated abundance of . Adding to the diet increased the level of and decreased the level of . Serum metabolomics revealed that levels of L-Glycine and Sn-Glycero-3-phosphocholine exhibited marked elevation in both the BL and BS groups, respectively. Furthermore, the study demonstrated that differential metabolites in the BL group were mainly enriched in amino acid metabolism pathways, while those in the BS group were chiefly concentrated in lipid metabolism pathways. However, this study acknowledges the limitations of its exclusive use of Ragdoll cats and its 35-day intervention period. It highlights the need for future research involving diverse breeds and longer durations. Overall, the data highlight and as cat nutritional supplements that improve immunity and maintain intestinal health.
近年来，随着猫数量的增加，猫的肠道健康受到越来越多的关注。益生菌对维持肠道稳态有积极作用。本研究旨在探讨益生菌（）和（）对猫的免疫力、炎症、抗氧化剂、肠道屏障、微生物群和血清代谢物的影响。36只猫（年龄超过1岁，体重3.48±0.71千克）被随机分为3组，分别饲喂基础日粮（CON组）、基础日粮+（BL组）和基础日粮+（BS组）。实验持续35天。粪便评分表明，和可以改善粪便评分。血清分析表明，添加这两种物质均可提高IgA、IgM、总抗氧化能力（T-AOC）和超氧化物歧化酶（SOD）水平，同时降低促炎因子肿瘤坏死因子-α（TNF-α）水平。此外，16S rRNA基因测序显示，和改变了粪便微生物群组成，其特征是的丰度升高。在日粮中添加可提高的水平并降低的水平。血清代谢组学显示，L-甘氨酸和Sn-甘油-3-磷酸胆碱水平在BL组和BS组中分别显著升高。此外，研究表明，BL组中的差异代谢物主要富集在氨基酸代谢途径中，而BS组中的差异代谢物主要集中在脂质代谢途径中。然而，本研究承认其仅使用布偶猫以及35天的干预期存在局限性。它强调了未来需要开展涉及不同品种和更长持续时间的研究。总体而言，数据突出了和作为改善免疫力和维持肠道健康的猫营养补充剂的作用。
