Jodl J, Stĕpán J, Lojda Z
Acta Univ Carol Med Monogr. 1977(78 Pt 2):65-70.
In a group of 26 child patients with coeliac sprue verified by clinical tests and biopsy, we observed a significant change in the proportion of the intestinal alkaline phosphatase isoenzyme in the serum in correlation to a gluten-free therapeutic diet. In untreated patients, in the active phase of the disease, intestinal AP isoenzyme activity rises in the serum and falls in the intestinal mucosa. In our experience, the change in activity is reversible within 3--5 days of instituting adequate treatment, i.e. a gluten-free diet. No such activity changes were observed in children with other forms of malabsorption syndrome (hepatogenic, pancreatogenic) or in the children in the control group. This test was found to be a suitable and sensitive method for indirect determination of the response of the intestinal mucosa to treatment in children with coeliac sprue.
在一组经临床检查和活检确诊为乳糜泻的26名儿童患者中，我们观察到血清中肠碱性磷酸酶同工酶比例与无麸质治疗饮食相关的显著变化。在未经治疗的疾病活动期患者中，血清中肠碱性磷酸酶同工酶活性升高，而肠黏膜中则降低。根据我们的经验，在采取适当治疗（即无麸质饮食）后的3至5天内，活性变化是可逆的。在患有其他形式吸收不良综合征（肝源性、胰腺源性）的儿童或对照组儿童中未观察到此类活性变化。该试验被认为是间接测定乳糜泻儿童肠黏膜对治疗反应的一种合适且敏感的方法。
