Lee Sungmin
Department of Speech-Language Pathology and Aural Rehabilitation, Tongmyong University, Busan, Korea.
J Audiol Otol. 2025 Oct;29(4):258-264. doi: 10.7874/jao.2025.00220. Epub 2025 Oct 20.
The auditory brainstem response (ABR) represents a critical tool for evaluating auditory pathways. Although absolute and inter-peak latencies (IPLs) are commonly analyzed, the differences between different stimulus types and presentation modes, particularly during binaural processing, remain underexplored. This study compared the absolute latencies, IPLs, and binaural interaction component (BIC) latencies of ABRs elicited by click and LS CE-chirp stimuli under both monaural and binaural conditions. The present study analyzed the clinical features of cochlear function in Ramsay-Hunt syndrome.
Twenty-one adults with normal hearing aged 22-25 years underwent ABR testing using click and LS CE-chirp stimuli under binaural, right ear, and left ear conditions. Their absolute latencies, IPLs, and BIC latencies for waves I, III, and V were recorded. BIC latencies were calculated by subtracting each subject's binaural wave latency from their mean monaural latency.
The subjects' LS CE-chirp stimuli elicited significantly longer wave V latencies under binaural vs monaural conditions, although their click-evoked ABRs did not show significant differences across the different presentation modes evaluated. The wave III latencies were significantly longer for the LS CE-chirp stimuli under the binaural and right-ear conditions. The IPLs showed stimulus- and ear-dependent differences, with LS CE-chirps evoking shorter IPLs vs. regular clicks under some conditions. The BIC latencies for waves III and V were significantly longer for the LS CE-chirp stimuli, whereas those for wave I showed no significant differences.
LS CE-chirp stimuli enhanced ABR detectability and revealed longer binaural processing times, particularly at higher auditory brainstem levels. These findings support the utility of LS CE-chirp in terms of assessing binaural integration and central auditory processing.
听性脑干反应（ABR）是评估听觉通路的重要工具。虽然绝对潜伏期和峰间潜伏期（IPL）常被分析，但不同刺激类型和呈现模式之间的差异，尤其是在双耳处理过程中，仍未得到充分研究。本研究比较了单耳和双耳条件下短声和低刺激率CE-啁啾刺激诱发的ABR的绝对潜伏期、IPL和双耳相互作用成分（BIC）潜伏期。本研究分析了拉姆齐-亨特综合征患者耳蜗功能的临床特征。
21名年龄在22 - 25岁的听力正常的成年人在双耳、右耳和左耳条件下使用短声和低刺激率CE-啁啾刺激进行ABR测试。记录他们I、III和V波的绝对潜伏期、IPL和BIC潜伏期。BIC潜伏期通过从每个受试者的单耳平均潜伏期减去其双耳波潜伏期来计算。
尽管在评估的不同呈现模式下，短声诱发的ABR没有显著差异，但受试者的低刺激率CE-啁啾刺激在双耳条件下诱发的V波潜伏期明显长于单耳条件。在双耳和右耳条件下，低刺激率CE-啁啾刺激的III波潜伏期明显更长。IPL表现出刺激和耳依赖性差异，在某些条件下，低刺激率CE-啁啾刺激诱发的IPL比常规短声更短。低刺激率CE-啁啾刺激的III波和V波的BIC潜伏期明显更长，而I波的BIC潜伏期没有显著差异。
低刺激率CE-啁啾刺激增强了ABR的可检测性，并显示出更长的双耳处理时间，尤其是在较高的听觉脑干水平。这些发现支持了低刺激率CE-啁啾在评估双耳整合和中枢听觉处理方面的实用性。
