Haas F, Bergofsky E H
J Clin Invest. 1972 Dec;51(12):3154-62. doi: 10.1172/JCI107142.
This study investigated the role of the mast cell in the pulmonary arterial pressor response to hypoxia. We found that pulmonary arteries 50-500 mu in diameter have a predictable distribution of perivascular mast cells; that such pulmonary mast cells are degranulated in vivo during alveolar hypoxia; that hypoxia releases histamine from mast cells isolated from the peritoneal cavity without apparent injury to the cells; and that histamine is released from the lung of intact guinea pigs during alveolar hypoxia, with the rise in pulmonary vascular resistance during this period proportional to the amount of histamine released. These data point to the perivascular pulmonary mast cell in the rat and guinea pig as an important structure in the mediation of the pulmonary pressor response to hypoxia, even though the responsible humoral vasoconstrictor released from such a cell may not be histamine, or histamine alone.
本研究调查了肥大细胞在肺动脉对缺氧的升压反应中的作用。我们发现，直径50 - 500微米的肺动脉周围血管肥大细胞分布具有可预测性；此类肺肥大细胞在肺泡缺氧时于体内发生脱颗粒；缺氧可使从腹腔分离出的肥大细胞释放组胺，且细胞无明显损伤；完整豚鼠肺在肺泡缺氧时释放组胺，在此期间肺血管阻力的升高与组胺释放量成正比。这些数据表明，大鼠和豚鼠的肺血管周围肥大细胞是介导肺对缺氧升压反应的重要结构，尽管从这种细胞释放的起作用的体液性血管收缩剂可能不是组胺，或不仅仅是组胺。
