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相似文献

1
Deletion of b5 immunoglobulin-bearing lymphocytes in allotype-suppressed rabbits.同种异型抑制兔中携带b5免疫球蛋白的淋巴细胞的缺失。
J Exp Med. 1973 Feb 1;137(2):254-64. doi: 10.1084/jem.137.2.254.
2
Endogenous synthesis of membrane b5 by lymphocytes from rabbits recovering from b5 allotype suppression.从b5同种异型抑制中恢复的兔淋巴细胞对膜b5的内源性合成。
J Immunol. 1973 Nov;111(5):1595-7.
3
Defective activation of b5 bearing lymphocytes in rabbits recovering from b5 allotype suppression.从B5同种异型抑制中恢复的兔子中，携带B5的淋巴细胞的激活缺陷。
Cell Immunol. 1974 Mar 30;11(1-3):231-8. doi: 10.1016/0008-8749(74)90023-9.
4
Allotype suppression in the rabbit. I. The ontogeny of cells bearing immunoglobulin of paternal allotype and the fate of these cells after treatment with antiallotype antisera.兔中的同种异型抑制。I. 携带父本同种异型免疫球蛋白的细胞的个体发生以及用抗同种异型抗血清处理后这些细胞的命运。
J Exp Med. 1973 Oct 1;138(4):764-74. doi: 10.1084/jem.138.4.764.
5
Restriction of gene expression in B lymphocytes and their progeny. I. Commitment to immunoglobulin allotype.B淋巴细胞及其后代中基因表达的限制。I. 对免疫球蛋白同种异型的定向。
J Exp Med. 1974 Mar 1;139(3):581-99. doi: 10.1084/jem.139.3.581.
6
In vitro studies on allotype suppression. III. compounds of antiallyotype serum active in release from allotype suppression.同种异型抑制的体外研究。III. 抗同种异型血清中可有效解除同种异型抑制的化合物
J Exp Med. 1975 Aug 1;142(2):332-45. doi: 10.1084/jem.142.2.332.
7
Antigen-secreting cells: enumeration of immunoglobulin-allotype-secreting cells in nonimmunized rabbits by means of hybrid-antibody-coated erythrocytes in a reverse hemolytic plaque assay.抗原分泌细胞：通过反向溶血空斑试验中杂交抗体包被的红细胞对未免疫兔中分泌免疫球蛋白同种异型的细胞进行计数。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1229-33. doi: 10.1073/pnas.71.4.1229.
8
Normal and altered phenotypic expression of immunoglobulin genes.免疫球蛋白基因的正常和改变的表型表达。
Fed Proc. 1975 Jan;34(1):40-6.
9
In vitro studies on allotype suppression. II. Regulation of antibody synthesis by anti-allotype serum.同种异型抑制的体外研究。II. 抗同种异型血清对抗体合成的调节。
J Immunol. 1975 Apr;114(4):1275-80.
10
Expression of kappa chain allotypes at the cell surface and in serum immunoglobulins of normal and allotype-suppressed heterozygous rabbits.正常及同种异型抑制杂合兔细胞表面和血清免疫球蛋白中κ链同种异型的表达。
Immunology. 1982 Jul;46(3):661-9.

引用本文的文献

1
Induction of lymphoid cell chimerism in noninbred, histocompatible rabbits. A new model for studying allotype suppression in the rabbit.在非近亲繁殖、组织相容性的兔子中诱导淋巴细胞嵌合体。一种研究兔子同种异型抑制的新模型。
J Exp Med. 1981 Oct 1;154(4):1085-99. doi: 10.1084/jem.154.4.1085.
2
Expression of kappa chain allotypes at the cell surface and in serum immunoglobulins of normal and allotype-suppressed heterozygous rabbits.正常及同种异型抑制杂合兔细胞表面和血清免疫球蛋白中κ链同种异型的表达。
Immunology. 1982 Jul;46(3):661-9.
3
Humoral and cellular aspects of immunoglobulin allotype suppression in the rabbit. II. Effect of beta locus suppression on immunoglobulin receptor-bearing lymphocytes.兔免疫球蛋白同种异型抑制的体液和细胞方面。II. β基因座抑制对携带免疫球蛋白受体淋巴细胞的影响。
Immunology. 1974 Feb;26(2):331-43.
4
Requirements for prolonged suppression of an idiotypic specificity in adult mice.成年小鼠中延长独特型特异性抑制的要求。
J Exp Med. 1973 Jun 1;137(6):1442-58. doi: 10.1084/jem.137.6.1442.
5
Allotype suppression in the rabbit. I. The ontogeny of cells bearing immunoglobulin of paternal allotype and the fate of these cells after treatment with antiallotype antisera.兔中的同种异型抑制。I. 携带父本同种异型免疫球蛋白的细胞的个体发生以及用抗同种异型抗血清处理后这些细胞的命运。
J Exp Med. 1973 Oct 1;138(4):764-74. doi: 10.1084/jem.138.4.764.
6
Cellular basis of an auto-anti-allotypic mechanism for the maintenance of chronic allotype suppression in the rabbit.兔慢性同种异型抑制维持中自身抗同种异型机制的细胞基础。
Immunology. 1989 Feb;66(2):238-45.
7
In vitro studies on allotype suppression. III. compounds of antiallyotype serum active in release from allotype suppression.同种异型抑制的体外研究。III. 抗同种异型血清中可有效解除同种异型抑制的化合物
J Exp Med. 1975 Aug 1;142(2):332-45. doi: 10.1084/jem.142.2.332.

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THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
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2
IMMUNOCHEMICAL IDENTIFICATION AND GENETICS OF RABBIT GAMMA-GLOBULIN ALLOTYPES.兔γ-球蛋白同种异型的免疫化学鉴定与遗传学
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A DIALYSIS TECHNIQUE FOR PREPARING FLUORESCENT ANTIBODY.一种制备荧光抗体的透析技术。
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Effect of maternal isoantibodies on the quantitative expression of two allelic genes controlling gamma-globulin allotypic specificities.母体同种抗体对控制γ-球蛋白同种异型特异性的两个等位基因定量表达的影响。
Nature. 1962 Aug 18;195:677-80. doi: 10.1038/195677a0.
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[Immunoelectrophoretic method for the analysis of mixtures of antigenic substances].[用于分析抗原物质混合物的免疫电泳法]
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Genetic regulation of immunoglobulin synthesis.免疫球蛋白合成的基因调控。
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7
Chronic allotype suppression in mice: an active regulatory process.小鼠中的慢性同种异型抑制：一种主动调节过程。
Ann N Y Acad Sci. 1971 Dec 31;190:212-20. doi: 10.1111/j.1749-6632.1971.tb13536.x.
8
Suppression of immunoglobulin G synthesis as a result of antibody-mediated suppression of immunoglobulin M synthesis in chickens.抗体介导抑制鸡免疫球蛋白M合成导致免疫球蛋白G合成受抑制。
Proc Natl Acad Sci U S A. 1970 Dec;67(4):1918-25. doi: 10.1073/pnas.67.4.1918.
9
Rabbit light chains lacking b-allotypic specificites. I. Isolation and characterization of light chains from normal and allotype suppressed homozygotes.缺乏b等位基因特异性的兔轻链。I. 来自正常和等位基因抑制纯合子的轻链的分离与特性分析。
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10
Immunoglobulins as cell receptors.作为细胞受体的免疫球蛋白。
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同种异型抑制兔中携带b5免疫球蛋白的淋巴细胞的缺失。

Deletion of b5 immunoglobulin-bearing lymphocytes in allotype-suppressed rabbits.

作者信息

Harrison M R, Mage R G, Davie J M

出版信息

J Exp Med. 1973 Feb 1;137(2):254-64. doi: 10.1084/jem.137.2.254.

DOI:10.1084/jem.137.2.254
PMID:4119585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139501/
Abstract

The proportion of peripheral blood lymphocytes with cell surface b5 immunoglobulin (Ig) was compared with serum b5 Ig levels in allotype-suppressed and recovering b5 homozygous rabbits in order to establish the cellular defect in suppression and to determine the relation between lymphocyte membrane Ig and secreted Ig of the same allotype. In rabbits fully suppressed for b5, the absence of circulating b5 Ig is reflected in a complete deletion of b5-bearing lymphocytes. During spontaneous escape from suppression, the appearance of b5-bearing lymphocytes precedes the appearance of detectable serum b5. During recovery from suppression b5-bearing lymphocytes recover rapidly toward normal levels, but circulating b5 levels remain chronically and disproportionately depressed.

摘要

比较了同种异型抑制和恢复中的b5纯合兔外周血中具有细胞表面b5免疫球蛋白（Ig）的淋巴细胞比例与血清b5 Ig水平，以确定抑制中的细胞缺陷，并确定淋巴细胞膜Ig与相同同种异型的分泌型Ig之间的关系。在b5完全被抑制的兔子中，循环b5 Ig的缺失反映在携带b5的淋巴细胞完全缺失。在自发从抑制状态逃脱的过程中，携带b5的淋巴细胞的出现先于可检测到的血清b5的出现。在从抑制状态恢复的过程中，携带b5的淋巴细胞迅速恢复到正常水平，但循环b5水平长期且不成比例地保持在低水平。