Grundström R, Holmberg G, Ledermann H, Livstedt B
Psychopharmacology (Berl). 1977 Oct 20;54(2):165-9. doi: 10.1007/BF00426774.
Doxepin (Quitaxon) at doses of 25, 50, and 75 mg was compared with diazepam 7.5, 15, and 22.5 mg, using as variables the percentage lowering of Critical Flicker Fusion (CFF) and the self-estimated degree of drowsiness. Single doses were given, and repeated effect determinations were made over 6 h. Clear dose-effect relations could be demonstrated. The two drugs differed in speed and duration of action and in steepness of effect increase with dose. Although there were good correlations between CFF effect and subjective drowsiness, it seemed that the two methods interrelated somewhat differently in the different types of drug. CFF was a more stable and reliable method than the subjective estimation of drowsiness. However, when comparing drugs belonging to different classes, both methods preferably should be used together.
将多塞平（Quitaxon）25毫克、50毫克和75毫克的剂量与地西泮7.5毫克、15毫克和22.5毫克的剂量进行比较，以临界闪烁融合（CFF）降低百分比和自我估计的嗜睡程度作为变量。给予单次剂量，并在6小时内重复进行效应测定。可以证明明确的剂量效应关系。这两种药物在作用速度和持续时间以及效应随剂量增加的陡度方面存在差异。尽管CFF效应与主观嗜睡之间存在良好的相关性，但在不同类型的药物中，这两种方法的相互关系似乎有所不同。CFF是一种比主观嗜睡估计更稳定、更可靠的方法。然而，在比较不同类别的药物时，最好同时使用这两种方法。
