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大鼠对吗啡耐受性的发展

The development of tolerance to morphine in the rat.

作者信息

Fernandes M, Kluwe S, Coper H

出版信息

Psychopharmacology (Berl). 1977 Oct 20;54(2):197-201. doi: 10.1007/BF00426780.

DOI:10.1007/BF00426780
PMID:412215
Abstract

Tolerance to various effects of morphine in the rat can be quantified by means of a shift of semi-logarithmic dose-response curves. Tolerance to analgesia (hot plate, acetic acid writhing), catalepsy, and the tilted plane develops in a closely similar manner. Also, the stimulating effects of about 1 mg/kg morphine-HC1 tested in an open-field procedure are somewhat less pronounced in chronically treated rats than in naive ones. There is no correlation between tolerance development and the acute ED50 of different tests.

摘要

大鼠对吗啡各种效应的耐受性可通过半对数剂量-反应曲线的位移来定量。对镇痛作用（热板法、醋酸扭体法）、僵住症和倾斜平面试验的耐受性以非常相似的方式发展。此外，在旷场试验中测试的约1mg/kg盐酸吗啡的刺激作用，在慢性处理的大鼠中比在未处理的大鼠中稍不明显。耐受性发展与不同试验的急性半数有效量（ED50）之间没有相关性。

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The development of tolerance to morphine in the rat.大鼠对吗啡耐受性的发展
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本文引用的文献

1
Behavioural and pharmacological studies on morphine-induced excitation of rats. Possible relation to brain catecholamines.吗啡诱发大鼠兴奋的行为学和药理学研究。与脑内儿茶酚胺的可能关系。
Psychopharmacologia. 1973;29(4):317-28. doi: 10.1007/BF00429279.
大鼠对尼古丁镇痛作用的联合耐受性和行为耐受性：甩尾试验和舔足试验。
Psychopharmacology (Berl). 2005 Jul;180(2):224-33. doi: 10.1007/s00213-005-2151-4. Epub 2005 Feb 5.
4
Cross-tolerance of associative and nonassociative morphine tolerance in the rat with mu- and kappa-specific opioids.大鼠中阿片μ受体和κ受体特异性阿片类药物对联合性和非联合性吗啡耐受性的交叉耐受性。
Psychopharmacology (Berl). 1996 Feb;123(3):289-96. doi: 10.1007/BF02246583.
5
In vivo apparent pA2 analysis in rats treated with either clocinnamox or morphine.用氯辛肟或吗啡治疗的大鼠体内表观pA2分析。
Psychopharmacology (Berl). 1996 May;125(2):113-9. doi: 10.1007/BF02249409.
6
Morphine-conditioned analgesia using a taste cue: dissociation of taste aversion and analgesia.使用味觉线索的吗啡条件性镇痛：味觉厌恶与镇痛的分离。
Psychopharmacology (Berl). 1994 Mar;114(2):269-74. doi: 10.1007/BF02244848.
7
Development and loss of tolerance to morphine in the rat.
Psychopharmacology (Berl). 1982;78(3):234-8. doi: 10.1007/BF00428157.
8
Log dose/response curve flattening in rats after daily injection of opiates.大鼠每日注射阿片类药物后对数剂量/反应曲线的平坦化
Psychopharmacology (Berl). 1980;71(1):51-61. doi: 10.1007/BF00433252.
9
Oxytocin diminishes heroin tolerance in mice.催产素可降低小鼠对海洛因的耐受性。
Psychopharmacology (Berl). 1985;86(3):377-9. doi: 10.1007/BF00432233.
10
Tolerance to hyperthermia produced by morphine in rat.大鼠对吗啡所致体温过高的耐受性。
Psychopharmacology (Berl). 1987;92(4):452-8. doi: 10.1007/BF00176477.