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The role of cytochrome P-450 in N-hydroxylation of 2-acetylaminofluorene.

作者信息

Thorgeirsson S S, Jollow D J, Sasame H A, Green I, Mitchell J R

出版信息

Mol Pharmacol. 1973 May;9(3):398-404.

PMID:4122821
Abstract
摘要

相似文献

1
The role of cytochrome P-450 in N-hydroxylation of 2-acetylaminofluorene.
Mol Pharmacol. 1973 May;9(3):398-404.
2
Relationship between NADH and NADPH oxidation during drug metabolism.药物代谢过程中NADH与NADPH氧化之间的关系。
Drug Metab Dispos. 1973 Jan-Feb;1(1):150-5.
3
Effect of enzyme inducers on substrate specificity of the cytochrome P-450's.酶诱导剂对细胞色素P-450底物特异性的影响。
Drug Metab Dispos. 1973 Jan-Feb;1(1):199-210.
4
On the mechanism of hydroxylation reactions catalyzed by cytochrome P-450.关于细胞色素P-450催化的羟基化反应机制
Drug Metab Dispos. 1973 Jan-Feb;1(1):92-7.
5
Mechanisms of inhibition of drug metabolic reactions.药物代谢反应的抑制机制。
Drug Metab Dispos. 1973 Jan-Feb;1(1):164-75.
6
Studies on the effects of methylmercury on ethylmorphine N-demethylase and aniline hydroxylase activities and on the conversion of cytochrome P-450 to cytochrome P-420.甲基汞对乙基吗啡N-脱甲基酶和苯胺羟化酶活性以及细胞色素P-450向细胞色素P-420转化的影响研究。
Drug Metab Dispos. 1974 May-Jun;2(3):259-66.
7
Role of phospholipid in the reconstituted liver microsomal mixed function oxidase system containing cytochrome P-450 and NADPH-cytochrome P-450 reductase.磷脂在含有细胞色素P - 450和NADPH - 细胞色素P - 450还原酶的重组肝微粒体混合功能氧化酶系统中的作用。
Drug Metab Dispos. 1973 Jan-Feb;1(1):156-61.
8
Perinatal development of tertiary amine N-oxidation and NADPH cytochrome C reduction in rat liver microsomes.大鼠肝微粒体中叔胺N-氧化和NADPH细胞色素C还原的围产期发育。
Res Commun Chem Pathol Pharmacol. 1971 Nov;2(6):793-805.
9
Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. II. Role of the type I drug-binding site of cytochrome P-450.肝微粒体中还原型三磷酸吡啶核苷酸依赖性混合功能氧化酶系统的二磷酸吡啶核苷酸协同作用降低。II. 细胞色素P-450 I型药物结合位点的作用。
Mol Pharmacol. 1973 Jul;9(4):470-85.
10
NADPH-cytochrome c reductase and its role in microsomal cytochrome P-450-dependent reactions.NADPH-细胞色素c还原酶及其在微粒体细胞色素P-450依赖性反应中的作用。
Drug Metab Dispos. 1973 Jan-Feb;1(1):121-8.

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Micronucleus incidence and hematological effects in bullfrog tadpoles (Rana catesbeiana) exposed to 2-acetylaminofluorene and 2-aminofluorene.暴露于2-乙酰氨基芴和2-氨基芴的牛蛙蝌蚪（牛蛙）的微核发生率和血液学效应。
Arch Environ Contam Toxicol. 1993 May;24(4):487-93. doi: 10.1007/BF01146167.
2
Differential induction of antipyrine metabolism by rifampicin.利福平对安替比林代谢的差异诱导作用。
Eur J Clin Pharmacol. 1981;21(2):155-60. doi: 10.1007/BF00637517.
3
Metabolic activation of aromatic amines and dialkylnitrosamines.芳香胺和二烷基亚硝胺的代谢活化
J Cancer Res Clin Oncol. 1981;99(1-2):125-36. doi: 10.1007/BF00412448.
4
Metabolism and activation of chemical carcinogens.化学致癌物的代谢与活化
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5
Inhibitory effect of carbon monoxide on the N- and ring-hydroxylation of 2-acetamidofluorene by hamster hepatic microsomal preparations.一氧化碳对仓鼠肝微粒体制剂中2-乙酰氨基芴的N-羟基化和环羟基化的抑制作用。
Biochem J. 1974 Nov;144(2):427-30. doi: 10.1042/bj1440427.
6
Role of mixed-function amine oxidases in N-hydroxylation of 2-acetamidofluorene by hamster liver microsomal preparations.混合功能胺氧化酶在仓鼠肝微粒体制剂对2-乙酰氨基芴进行N-羟基化反应中的作用。
Biochem J. 1973 Dec;136(4):1137-40. doi: 10.1042/bj1361137.
7
Effects of vitamin A on the metabolism and mutagenicity of 2AAF in vitro and on the covalent binding to rat liver DNA/RNA in vivo.维生素A对2-乙酰氨基芴在体外的代谢和致突变性以及在体内与大鼠肝脏DNA/RNA共价结合的影响。
Arch Toxicol. 1985 Aug;57(3):178-83. doi: 10.1007/BF00290884.
8
Effect of detergents on the N-and ring-hydroxylation of 2-acetamidofluorene by hamster liver microsomal preparations.去污剂对仓鼠肝微粒体制剂催化2-乙酰氨基芴的N-羟基化和环羟基化的影响。
Biochem J. 1976 Dec 15;160(3):821-4. doi: 10.1042/bj1600821.
9
Genetic aspects of toxicity during development.发育过程中毒性的遗传学方面。
Environ Health Perspect. 1976 Dec;18:35-45. doi: 10.1289/ehp.761835.
10
Ring-andN-hydroxylation of 2-acetamidofluorene by rat liver reconstituted cytochrome P-450 enzyme system.大鼠肝脏重组细胞色素P-450酶系统对2-乙酰氨基芴的环化和N-羟基化作用。
Biochem J. 1975 Sep;150(3):561-4. doi: 10.1042/bj1500561.