Macía Manuel, Fernández-Juárez Gema, Ávila Ana I, Espino Mar, Espinosa Mario, Fulladosa Xavier, García-Carro Clara, Goicoechea Marian, Morales Enrique, Quintana Luis F, Rojas-Rivera Jorge E, Praga Manuel
Hospital Universitario Nuestra Señora de la Candelaria, Tenerife, Spain.
Hospital Universitario La Paz, Instituto de Investigacion IdiPaz, Madrid, Spain.
Nefrologia (Engl Ed). 2025 Nov;45(9):501354. doi: 10.1016/j.nefroe.2025.501354. Epub 2025 Nov 12.
In 2023, the Spanish Society of Nephrology's Glomerular Diseases Study Group (GLOSEN) published a consensus document containing the most pertinent information and clinical recommendations for the diagnosis, treatment, and follow-up of lupus nephritis (LN). GLANCE is a project that emerged from the need to evaluate the extent of knowledge and application of these GLOSEN recommendations in routine clinical practice for the management of LN. To achieve this, an online self-administered survey was conducted to gather opinions on the recommendations and assess their impact on clinical practice. Fifty-one Spanish nephrologists (n = 51) with more than three years of experience in managing LN and handling more than one LN patient per month, participated in the survey. All participants demonstrated a comprehensive understanding and high overall acceptance of the GLOSEN recommendations. However, discrepancies were noted regarding criteria for partial remission and relapse, as well as treatment goals during the initial months of progression, underscoring the need for a more detailed consensus. Other findings highlighted the limited number of nephrologists using specific scales to assess extrarenal manifestations and the tendency to extend immunosuppressive treatments beyond the recommended 3-5-year period outlined in the document. This emphasizes the necessity for further studies on the discontinuation of these drugs and their association with the risk of relapse in LN.
2023年，西班牙肾脏病学会肾小球疾病研究组（GLOSEN）发布了一份共识文件，其中包含狼疮性肾炎（LN）诊断、治疗及随访方面最相关的信息和临床建议。GLANCE是一个因需要评估这些GLOSEN建议在LN管理的常规临床实践中的知识掌握程度和应用情况而产生的项目。为实现这一目标，开展了一项在线自我管理调查，以收集对这些建议的意见并评估其对临床实践的影响。51名在LN管理方面有三年以上经验且每月处理不止一名LN患者的西班牙肾脏病专家参与了该调查。所有参与者对GLOSEN建议都表现出全面的理解和高度的总体接受度。然而，在部分缓解和复发的标准以及疾病进展最初几个月的治疗目标方面存在差异，这突出表明需要达成更详细的共识。其他研究结果强调，使用特定量表评估肾外表现的肾脏病专家数量有限，以及免疫抑制治疗时间倾向于超过文件中建议的3至5年。这凸显了对这些药物停药及其与LN复发风险关联进行进一步研究的必要性。
