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将人横纹肌肉瘤细胞接种到经抗胸腺细胞血清处理的NIH瑞士小鼠体内后发现的一种C型病毒。

A type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with antithymocyte serum.

作者信息

Todaro G J, Arnstein P, Parks W P, Lennette E H, Huebner R J

出版信息

Proc Natl Acad Sci U S A. 1973 Mar;70(3):859-62. doi: 10.1073/pnas.70.3.859.

Abstract

A type-C RNA virus has been isolated that replicates readily in human and other primate cells. It was obtained from a human rhabdomyosarcoma cell (RD) that had been serially transplanted in immunosuppressed NIH Swiss mice, a strain of mouse from which infectious type-C virus has not been isolated. Various other human tumor cells, similarly transplanted, remained free of overt type-C virus expression. The virus growing in the RD cells, AT-124, has a group-specific antigen and an RNA-dependent DNA polymerase immunologically related to murine type-C viruses, but a host range similar to that of the RD-114 virus. The new isolate is either a previously undescribed, endogenous type-C virus from NIH Swiss mice or a recombinant with both mouse and human type-C genetic information.

摘要

一种C型RNA病毒已被分离出来,它能在人类和其他灵长类细胞中轻易复制。它是从一株在免疫抑制的NIH瑞士小鼠(一种尚未分离出感染性C型病毒的小鼠品系)中连续传代移植的人横纹肌肉瘤细胞(RD)中获得的。其他各种同样移植的人类肿瘤细胞均未出现明显的C型病毒表达。在RD细胞中生长的病毒AT - 124具有群特异性抗原和一种与鼠类C型病毒在免疫学上相关的RNA依赖性DNA聚合酶,但其宿主范围与RD - 114病毒相似。这种新分离株要么是一种来自NIH瑞士小鼠的此前未被描述的内源性C型病毒,要么是一种兼具小鼠和人类C型遗传信息的重组体。

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