Yamamoto S, Greaves M W, Plummer V
Immunology. 1973 Jun;24(6):1007-12.
The effect of cytochalasin B (which selectively inhibits the function of cytoplasmic contractile microfilaments) on IgE-mediated hypersensitivity in human skin was studied. Cytochalasin B inhibited the antigen-induced histamine release from human skin slices sensitized passively with human reaginic serum. The magnitude of inhibition of histamine release was related to the duration of preincubation of sensitized skin slices with cytochalasin B. The effect of cytochalasin B on antigen-induced histamine release from sensitized skin was reversible, indicating that the inhibition of histamine release may be due to the inhibition of contraction of cytoplasmic microfilaments in sensitized target cells by cytochalasin B.
研究了细胞松弛素B（其选择性抑制细胞质收缩微丝的功能）对人皮肤中IgE介导的超敏反应的影响。细胞松弛素B抑制了用人反应素血清被动致敏的人皮肤切片中抗原诱导的组胺释放。组胺释放的抑制程度与致敏皮肤切片与细胞松弛素B预孵育的持续时间有关。细胞松弛素B对抗原诱导的致敏皮肤中组胺释放的作用是可逆的，这表明组胺释放的抑制可能是由于细胞松弛素B抑制了致敏靶细胞中细胞质微丝的收缩。
