人乳中存在肿瘤病毒的进一步证据：核心物质的产生。
Further evidence for oncornaviruses in human milk: the production of cores.
作者信息
Feldman S P, Schlom J, Spiegelman S
出版信息
Proc Natl Acad Sci U S A. 1973 Jul;70(7):1976-80. doi: 10.1073/pnas.70.7.1976.
Abstract
Cores, or nucleoids, have been isolated from particles in human milk. The cores have a density of 1.26-1.27 g/ml and contain a 60-70S RNA in association with an RNA-instructed DNA polymerase. The data offer further evidence of similarity between human milk particles and animal RNA tumor viruses. In addition, core isolation provides a new method for detection of these particles by minimizing the difficulties generated by the presence of cell-associated debris often found in the density region (1.16-1.19 g/ml) characteristic of the intact virion. The procedures described now make available preparations of purified subviral components of a putative human RNA tumor virus.
摘要
已从人乳中的颗粒中分离出核心或核样体。这些核心的密度为1.26 - 1.27克/毫升，含有一种60 - 70S RNA，并与一种RNA指导的DNA聚合酶相关联。这些数据进一步证明了人乳颗粒与动物RNA肿瘤病毒之间的相似性。此外，核心分离提供了一种新的检测这些颗粒的方法，可将完整病毒体特征性密度区域（1.16 - 1.19克/毫升）中经常存在的细胞相关碎片所产生的困难降至最低。现在所描述的方法可制备出一种假定的人RNA肿瘤病毒的纯化亚病毒成分制剂。
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