人脑肿瘤中具有高分子量RNA和RNA指导的DNA聚合酶的颗粒。
Particles with RNA of high molecular weight and RNA-directed DNA polymerase in human brain tumors.
作者信息
Cuatico W, Cho J R, Spiegelman S
出版信息
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2789-93. doi: 10.1073/pnas.70.10.2789.
Abstract
We have previously shown that neoplastic cells of human breast cancers, leukemias, lymphomas, and sarcomas contain particles similar to the viruses that have been established as etiologic agents of these diseases in mice. The present paper concerns tumors of the central nervous system for which no suitable animal model or corresponding virus exists. Nevertheless, using the simultaneous detection test, we showed that human brain tumors contain 70S RNA and RNA-directed DNA polymerase encapsulated in a particulate component possessing a density of 1.17 g/ml. These particles satisfy the three diagnostic criteria that characterize RNA tumor viruses of animals. 24 Out of 26 (92%) of the most malignant (glioblastoma and medulloblastoma) brain tumors examined contained these virus-like entities.
摘要
我们之前已经表明，人类乳腺癌、白血病、淋巴瘤和肉瘤的肿瘤细胞含有与已被确定为小鼠这些疾病病原体的病毒相似的颗粒。本文关注的是中枢神经系统肿瘤，对于这类肿瘤不存在合适的动物模型或相应病毒。然而，通过同步检测试验，我们发现人类脑肿瘤含有70S RNA和RNA指导的DNA聚合酶，它们被包裹在一种密度为1.17 g/ml的颗粒成分中。这些颗粒符合表征动物RNA肿瘤病毒的三个诊断标准。在检查的26个最恶性的（胶质母细胞瘤和髓母细胞瘤）脑肿瘤中，有24个（92%）含有这些病毒样实体。
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