慢性血液透析对慢性肾衰竭患者甲状腺功能的影响。
Effects of chronic hemodialysis on thyroid function in chronic renal failure.
作者信息
Silverberg D S, Ulan R A, Fawcett D M, Dossetor J B, Grace M, Bettcher K
出版信息
Can Med Assoc J. 1973 Aug 18;109(4):282-6.
Thyroid function was studied in 54 patients undergoing chronic hemodialysis. Serum thyroxine, triiodothyronine and free thyroxine and the free thyroxine index were significantly lower than normal. The levels of both serum thyroxine and the free thyroxine index tended to fall progressively the longer the patients were on hemodialysis. These findings, in association with low serum TSH levels and normal increase in radioactive iodine uptake by the thyroid after TSH injection, suggest that a defect in pituitary secretion of TSH may be responsible. Although some patients experienced symptomatic improvement after treatment with L-thyroxine the efficacy of this form of treatment in patients on chronic hemodialysis has not yet been established.
对54例接受慢性血液透析的患者的甲状腺功能进行了研究。血清甲状腺素、三碘甲状腺原氨酸、游离甲状腺素及游离甲状腺素指数均显著低于正常水平。患者接受血液透析的时间越长，血清甲状腺素和游离甲状腺素指数水平越呈逐渐下降趋势。这些发现，结合低血清促甲状腺激素水平以及注射促甲状腺激素后甲状腺放射性碘摄取正常增加，提示垂体促甲状腺激素分泌缺陷可能是病因。尽管一些患者在接受左甲状腺素治疗后症状有所改善，但这种治疗方式对慢性血液透析患者的疗效尚未得到证实。
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