对肽聚糖具有抗体特异性的同源兔7S抗IgG。
Homogenous rabbit 7S anti-IgG with antibody specificity for peptidoglycan.
作者信息
Bokisch V A, Chiao J W, Bernstein D, Krause R M
出版信息
J Exp Med. 1973 Nov 1;138(5):1184-93. doi: 10.1084/jem.138.5.1184.
Abstract
The relationship between 7S anti-IgG and antibodies to streptococcal cell wall peptidoglycan was examined for four streptococcal Group C antisera. Homogeneous 7S anti-IgG components in these sera were isolated by means of an IgG immunoadsorbent column. For two of the four antisera, the anti-peptidoglycan activity of the 7S anti-IgG had specificity for the pentapeptide, L-Ala-D-Glu-gamma-L-Lys-D-Ala-D-Ala, the antigenic determinant of peptidoglycan, as well as for the Fc of IgG. Detailed studies on the 7S anti-IgG from one of the antisera revealed that the pentapeptide inhibited the coprecipitation reaction of 7S anti-IgG R3387 with antigen-antibody complexes and the precipitin reaction between 7S anti-IgG R3387 and its anti-idiotype serum.
摘要
针对四种C群链球菌抗血清，研究了7S抗IgG与抗链球菌细胞壁肽聚糖抗体之间的关系。通过IgG免疫吸附柱从这些血清中分离出均一的7S抗IgG成分。在这四种抗血清中的两种中，7S抗IgG的抗肽聚糖活性对肽聚糖的抗原决定簇五肽L-Ala-D-Glu-γ-L-Lys-D-Ala-D-Ala以及IgG的Fc具有特异性。对其中一种抗血清的7S抗IgG进行的详细研究表明，五肽抑制了7S抗IgG R3387与抗原-抗体复合物的共沉淀反应以及7S抗IgG R3387与其抗独特型血清之间的沉淀素反应。
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