内源性RNA C型病毒组特异性抗原在哺乳动物细胞中的表达。
Expression of endogenous RNA C-type virus group-specific antigens in mammalian cells.
作者信息
Stephenson J R, Aaronson S A
出版信息
J Virol. 1973 Sep;12(3):564-9. doi: 10.1128/JVI.12.3.564-569.1973.
Abstract
Highly sensitive and specific radioimmunoassays are described for quantitation of the intraspecies determinants of several mammalian C-type viral group-specific (gs) antigens. An interspecies (gs-3) immunoassay has been developed which has both the broad reactivity and great sensitivity necessary for detection of C-type viruses where intraspecies gs assays are not available. By using these immunoassays, the expression of endogenous virus-specified gs antigens in mammalian cells of different species has been studied. Whereas mouse gs antigen was clearly detectable in tissue culture cells of several mouse strains, the respective gs antigens of rat, cat, Chinese hamster, woolly monkey, and gibbon ape were not detectable in cells of those species, using assays of comparable sensitivity. Thus, differences exist in the level of endogenous virus expression in cells of different mammalian species.
摘要
本文描述了用于定量几种哺乳动物C型病毒群特异性（gs）抗原种内决定簇的高灵敏度和特异性放射免疫测定法。已开发出一种种间（gs-3）免疫测定法，它具有检测C型病毒所需的广泛反应性和高灵敏度，而在无法进行种内gs测定时可使用该方法。通过使用这些免疫测定法，研究了不同物种哺乳动物细胞中内源性病毒特异性gs抗原的表达情况。在几种小鼠品系的组织培养细胞中可清晰检测到小鼠gs抗原，而使用灵敏度相当的测定法时，在大鼠、猫、中国仓鼠、绒毛猴和长臂猿等物种的细胞中未检测到相应的gs抗原。因此，不同哺乳动物物种细胞中内源性病毒的表达水平存在差异。
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