BALB-c细胞的内源性C型病毒：自发诱导和化学诱导的频率
Endogenous C-type viruses of BALB-c cells: frequencies of spontaneous and chemical induction.
作者信息
Aaronson S A, Dunn C Y
出版信息
J Virol. 1974 Jan;13(1):181-5. doi: 10.1128/JVI.13.1.181-185.1974.
Abstract
A sensitive biological assay has been developed for studying the frequency of virus induction from mouse cells containing poorly infectious endogenous C-type viruses. A low spontaneous frequency of virus activation of one but not a second endogenous virus of BALB/c cells has been demonstrated. The resistance of BALB/c cells to superinfection by the more inducible virus appears to be absolute, whereas resistance to the other virus is only relative. Thus, the evidence indicates that the BALB/c cell exerts differential effects at two levels of regulation on the expression of its biologically distinguishable endogenous C-type viruses.
摘要
已开发出一种灵敏的生物学检测方法，用于研究从含有感染性较弱的内源性C型病毒的小鼠细胞中诱导病毒的频率。已证明BALB/c细胞的一种内源性病毒而非第二种内源性病毒的病毒激活自发频率较低。BALB/c细胞对更易诱导的病毒的超感染具有绝对抗性，而对另一种病毒的抗性只是相对的。因此，有证据表明BALB/c细胞在两个调控水平上对其生物学上可区分的内源性C型病毒的表达发挥不同的作用。
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