丙咪嗪在患者体内的稳态动力学 - Suppr

Steady-state kinetics of imipramine in patients.

作者信息

Gram L F, Sondergaard I, Christiansen J, Petersen G O, Bech P, Reisby N, Ibsen I, Ortmann J, Nagy A, Dencker S J, Jacobsen O, Krautwald O

出版信息

Psychopharmacology (Berl). 1977 Nov 15;54(3):255-61. doi: 10.1007/BF00426573.

DOI:10.1007/BF00426573

PMID:413142

Abstract

摘要

相似文献

Steady-state kinetics of imipramine in patients.丙咪嗪在患者体内的稳态动力学

Psychopharmacology (Berl). 1977 Nov 15;54(3):255-61. doi: 10.1007/BF00426573.

Pharmacokinetic correlation between in vitro hepatic microsomal enzyme kinetics and in vivo metabolism of imipramine and desipramine in rats.

J Pharm Sci. 1990 Apr;79(4):281-7. doi: 10.1002/jps.2600790402.

Active metabolites of imipramine and desipramine in man.

Clin Pharmacol Ther. 1982 Mar;31(3):393-401. doi: 10.1038/clpt.1982.50.

Kinetic properties of the metabolism of imipramine and desipramine in isolated rat hepatocytes.丙咪嗪和地昔帕明在离体大鼠肝细胞中代谢的动力学特性。

Biochem Pharmacol. 1990 Jan 15;39(2):367-72. doi: 10.1016/0006-2952(90)90036-k.

Imipramine and desipramine disposition in the elderly.老年人体内丙咪嗪和地昔帕明的代谢情况

J Pharmacol Exp Ther. 1985 Jan;232(1):183-8.

The distribution of imipramine and desipramine in rat brain regions after single and chronic administration of imipramine.

Pol J Pharmacol Pharm. 1984 Jan-Feb;36(1):21-6.

First-pass metabolism of imipramine and desipramine: impact of the sparteine oxidation phenotype.

Clin Pharmacol Ther. 1988 Apr;43(4):400-6. doi: 10.1038/clpt.1988.50.

Imipramine metabolites in blood of patients during therapy and after overdose.

Clin Pharmacol Ther. 1983 Mar;33(3):335-42. doi: 10.1038/clpt.1983.42.

The route of administration of imipramine as a factor affecting formation of its metabolite desipramine.丙咪嗪的给药途径作为影响其代谢产物地昔帕明形成的一个因素。

J Pharm Pharmacol. 1982 Oct;34(10):678-80. doi: 10.1111/j.2042-7158.1982.tb04703.x.

Inhibition of biogenic amines uptake by imipramine, desipramine, 2 OH-imipramine and 2 OH-desipramine in rat brain.丙咪嗪、地昔帕明、2-羟基丙咪嗪和2-羟基地昔帕明对大鼠脑内生物胺摄取的抑制作用。

Life Sci. 1979 Jan 1;24(1):21-8. doi: 10.1016/0024-3205(79)90275-3.

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A selective test for antidepressant treatments using rats bred for stress-induced reduction of motor activity in the swim test.一种使用在游泳试验中因应激导致运动活动减少而培育的大鼠进行抗抑郁治疗的选择性试验。

Psychopharmacology (Berl). 2005 Oct;182(1):9-23. doi: 10.1007/s00213-005-0048-x. Epub 2005 Sep 29.

Clinical pharmacokinetics of drugs used to treat urge incontinence.用于治疗急迫性尿失禁药物的临床药代动力学

Clin Pharmacokinet. 2003;42(14):1243-85. doi: 10.2165/00003088-200342140-00004.

Pharmacokinetic optimisation of tricyclic antidepressant therapy.三环类抗抑郁药治疗的药代动力学优化

Clin Pharmacokinet. 1993 Apr;24(4):301-18. doi: 10.2165/00003088-199324040-00004.

The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study.丙咪嗪的N-去甲基化与S-美芬妥英氧化（S/R比值）相关。一项群体研究。

Br J Clin Pharmacol. 1993 Mar;35(3):331-4.

Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications.老年人抗抑郁药的临床药代动力学。治疗意义。

Clin Pharmacokinet. 1993 Feb;24(2):141-60. doi: 10.2165/00003088-199324020-00004.

Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms--a population study.与司巴丁和甲妥英氧化多态性相关的丙咪嗪代谢——一项群体研究。

Br J Clin Pharmacol. 1995 Apr;39(4):433-9. doi: 10.1111/j.1365-2125.1995.tb04473.x.

Plasma concentration and clinical effect in imipramine treatment of childhood enuresis.

Clin Pharmacokinet. 1980 Jul-Aug;5(4):386-93. doi: 10.2165/00003088-198005040-00006.

Citalopram, a selective serotonin reuptake inhibitor: clinical antidepressive and long-term effect--a phase II study.西酞普兰，一种选择性5-羟色胺再摄取抑制剂：临床抗抑郁及长期疗效——一项II期研究

Psychopharmacology (Berl). 1982;77(3):199-204. doi: 10.1007/BF00464566.

Dose-dependent kinetics of imipramine in elderly patients.

Psychopharmacology (Berl). 1981;75(4):354-7. doi: 10.1007/BF00435852.

Cardiovascular effect of imipramine and nortriptyline in elderly patients.丙咪嗪和去甲替林对老年患者的心血管影响。

Psychopharmacology (Berl). 1981;74(4):360-4. doi: 10.1007/BF00432748.

本文引用的文献

Imipramine metabolism in man. A study of urinary metabolites after administration of radioactive imipramine.人体内丙咪嗪的代谢。放射性丙咪嗪给药后尿中代谢产物的研究。

Psychopharmacologia. 1967 Aug 4;11(3):255-64. doi: 10.1007/BF00405231.

Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds.使用丙咪嗪类化合物治疗期间单甲基化三环类抗抑郁药的血浆水平。

Life Sci. 1967 Sep 1;6(17):1895-903. doi: 10.1016/0024-3205(67)90218-4.

Influence of neuroleptics and benzodiazepines on metabolism of tricyclic antidepressants in man.

Am J Psychiatry. 1974 Aug;131(8):863-6. doi: 10.1176/ajp.131.8.863.

Binding of basic and acidic drugs to rat tissue subcellular fractions.

Chem Biol Interact. 1974 Mar;8(3):151-62. doi: 10.1016/0009-2797(74)90037-4.

Effects of physical stress on the disposition of drugs eliminated by the liver in man.体力应激对人体肝脏消除药物处置的影响。

J Pharmacol Exp Ther. 1974 Jan;188(1):1-7.

Clearance concepts in pharmacokinetics.药代动力学中的清除概念。

J Pharmacokinet Biopharm. 1973 Apr;1(2):123-36. doi: 10.1007/BF01059626.

Benzodiazepines and tricyclic antidepressant plasma levels.苯二氮䓬类药物和三环类抗抑郁药的血浆水平。

Br Med J. 1973 Jul 7;3(5870):18-20. doi: 10.1136/bmj.3.5870.18.

Pharmacokinetics of nortriptyline in man after single and multiple oral doses: the predictability of steady-state plasma concentrations from single-dose plasma-level data.单剂量和多剂量口服后去甲替林在人体内的药代动力学：根据单剂量血浆水平数据预测稳态血浆浓度

Eur J Clin Pharmacol. 1972 Mar;4(2):82-91. doi: 10.1007/BF00562502.

Metabolism of tricyclic antidepressants. A review.三环类抗抑郁药的代谢。综述。

Dan Med Bull. 1974 Oct;21(6):218-31.

Factors affecting drug metabolism.影响药物代谢的因素。

Ann N Y Acad Sci. 1971 Jul 6;179:43-66. doi: 10.1111/j.1749-6632.1971.tb46890.x.

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