Mian N, Cowen D M
Br J Cancer. 1974 Jun;29(6):438-46. doi: 10.1038/bjc.1974.96.
Activities of 12 glycosidases and of β-D-glucuronidase were measured in liver, kidney and in the gastrointestinal tract of rats and mice. The activities of different enzymes varied not only within one tissue but also among different tissues. In rats injected with 1,2-dimethylhydrazine, a many fold increase in N-acetyl-β-D-glucosaminidase, N-acetyl-β-D-galactosaminidase, β-D-galactosidase and α-L-fucosidase was found in colonic tumours and colonic mucosa. These enzymes were elevated significantly in the kidney of tumour bearing animals as well. Liver and other parts of the gastrointestinal tract showed an increase only in N-acetyl-hexosaminidase with the appearance of colonic tumours. In treated mice, 2 N-acetylhexosaminidases were elevated in colon, duodenum, liver and kidney. However, in liver and kidney, β-D-galactosidase was also significantly increased.
在大鼠和小鼠的肝脏、肾脏以及胃肠道中测定了12种糖苷酶和β - D - 葡萄糖醛酸酶的活性。不同酶的活性不仅在一个组织内有所不同，而且在不同组织之间也存在差异。在注射了1,2 - 二甲基肼的大鼠中，在结肠肿瘤和结肠黏膜中发现N - 乙酰 - β - D - 氨基葡萄糖苷酶、N - 乙酰 - β - D - 半乳糖苷酶、β - D - 半乳糖苷酶和α - L - 岩藻糖苷酶的活性增加了许多倍。在荷瘤动物的肾脏中，这些酶也显著升高。随着结肠肿瘤的出现，肝脏和胃肠道的其他部位仅N - 乙酰己糖胺酶有所增加。在接受治疗的小鼠中，结肠、十二指肠、肝脏和肾脏中的2种N - 乙酰己糖胺酶升高。然而，在肝脏和肾脏中，β - D - 半乳糖苷酶也显著增加。
