Mian N, Cowen D M, Nutman C A
Br J Cancer. 1974 Sep;30(3):231-7. doi: 10.1038/bjc.1974.186.
Activities of N-acetyl-β-D-glucosaminidase, N-acetyl-β-D-galactosaminidase, β-D-galactosidase and α-L-fucosidase were measured in rat colonic tumours induced by 1,2-dimethylhydrazine. Tumours varied considerably in their enzyme content, not only from different animals but also from the same animals. Enzymatic heterogeneity among tumours appeared to be related to their site of origin in the colon. The descending colon, which after the DMH treatment showed a significant increase in the levels of glycosidases, also gave rise to a larger number of adenocarcinomata than other parts of the colon. The relative changes in the activities of four glycosidases seemed to show a good correlation.
对由1,2 - 二甲基肼诱导的大鼠结肠肿瘤中的N - 乙酰 - β - D - 氨基葡萄糖苷酶、N - 乙酰 - β - D - 半乳糖胺酶、β - D - 半乳糖苷酶和α - L - 岩藻糖苷酶的活性进行了测定。肿瘤的酶含量差异很大，不仅在不同动物之间，而且在同一动物的不同肿瘤之间。肿瘤之间的酶异质性似乎与其在结肠中的起源部位有关。经二甲基肼处理后，降结肠中糖苷酶水平显著升高，与结肠其他部位相比，降结肠产生的腺癌数量也更多。四种糖苷酶活性的相对变化似乎显示出良好的相关性。
