通过淋巴细胞膜免疫荧光研究HL-A抗原与β2-微球蛋白之间的关系。
Relationship between HL-A antigens and beta-2-microglobulin as studied by immunofluorescence on the lymphocyte membrane.
作者信息
Neauport-Sautes C, Bismuth A, Kourilsky F M, Manuel Y
出版信息
J Exp Med. 1974 Apr 1;139(4):957-68. doi: 10.1084/jem.139.4.957.
Abstract
The antibody-induced redistribution of beta2-microglobulin (beta2-micro) and HL-A antigens on the surface of living lymphocytes was studied by immunofluorescence. When all beta2-micro was redistributed on the lymphocyte membrane by specific rabbit antibodies and goat antirabbit Ig conjugates, the HL-A antigens were no more detectable with anti-HL-A conjugates outside the beta2-micro caps already formed. However, the redistribution of HL-A antigens fails to provoke the redistribution of all detectable beta2-micro molecules. These results suggest that HL-A antigens may be associated with beta2-micro at the cell surface, but that all beta2-micro molecules are not bound to HL-A antigens.
摘要
通过免疫荧光法研究了抗体诱导的β2-微球蛋白（β2-micro）和HL-A抗原在活淋巴细胞表面的重新分布。当所有β2-micro通过特异性兔抗体和山羊抗兔Ig结合物在淋巴细胞膜上重新分布时，在已经形成的β2-micro帽之外，用抗HL-A结合物再也检测不到HL-A抗原。然而，HL-A抗原的重新分布未能引发所有可检测到的β2-micro分子的重新分布。这些结果表明，HL-A抗原可能在细胞表面与β2-micro相关联，但并非所有β2-micro分子都与HL-A抗原结合。
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