Fellous M, Günther E, Kemler R, Wiels J, Berger R, Guenet J L, Jakob H, Jacob F
J Exp Med. 1978 Jul 1;148(1):58-70. doi: 10.1084/jem.148.1.58.
The expression of the H-Y antigen has been tested on several human lymphoid lines and mouse teratocarcinoma cell lines during differentiation. The human male lymphoid cell line Raji is a very useful target for studies of the H-Y antigen by lymphocytotoxicity test with rat anti-H-Y sera. With a few exceptions, all cells carrying the Y chromosome were H-Y positive. One of the exceptions is the human Daudi cell line which, besides lacking H-Y antigen, also lacks beta2-microglobulin. We have studied a possible association between the H-Y antigen, beta2-microglobulin, and HLA antigen with redistribution experiments. The results strongly suggest that H-Y antigen is not associated with HLA antigens but with beta2-microglobulin.
在分化过程中，已经在几种人类淋巴细胞系和小鼠畸胎瘤细胞系上检测了H-Y抗原的表达。人类男性淋巴细胞系Raji是通过用大鼠抗H-Y血清进行淋巴细胞毒性试验来研究H-Y抗原的非常有用的靶标。除了少数例外，所有携带Y染色体的细胞都是H-Y阳性的。例外之一是人类Daudi细胞系，它除了缺乏H-Y抗原外，还缺乏β2-微球蛋白。我们通过再分布实验研究了H-Y抗原、β2-微球蛋白和HLA抗原之间可能的关联。结果强烈表明，H-Y抗原与HLA抗原无关，而是与β2-微球蛋白有关。
