人类淋巴细胞及分化的小鼠畸胎瘤细胞系中H-Y雄性抗原与β2-微球蛋白的关联。
Association of the H-Y male antigen with beta2-microglobulin on human lymphoid and differentiated mouse teratocarcinoma cell lines.
作者信息
Fellous M, Günther E, Kemler R, Wiels J, Berger R, Guenet J L, Jakob H, Jacob F
出版信息
J Exp Med. 1978 Jul 1;148(1):58-70. doi: 10.1084/jem.148.1.58.
Abstract
The expression of the H-Y antigen has been tested on several human lymphoid lines and mouse teratocarcinoma cell lines during differentiation. The human male lymphoid cell line Raji is a very useful target for studies of the H-Y antigen by lymphocytotoxicity test with rat anti-H-Y sera. With a few exceptions, all cells carrying the Y chromosome were H-Y positive. One of the exceptions is the human Daudi cell line which, besides lacking H-Y antigen, also lacks beta2-microglobulin. We have studied a possible association between the H-Y antigen, beta2-microglobulin, and HLA antigen with redistribution experiments. The results strongly suggest that H-Y antigen is not associated with HLA antigens but with beta2-microglobulin.
摘要
在分化过程中，已经在几种人类淋巴细胞系和小鼠畸胎瘤细胞系上检测了H-Y抗原的表达。人类男性淋巴细胞系Raji是通过用大鼠抗H-Y血清进行淋巴细胞毒性试验来研究H-Y抗原的非常有用的靶标。除了少数例外，所有携带Y染色体的细胞都是H-Y阳性的。例外之一是人类Daudi细胞系，它除了缺乏H-Y抗原外，还缺乏β2-微球蛋白。我们通过再分布实验研究了H-Y抗原、β2-微球蛋白和HLA抗原之间可能的关联。结果强烈表明，H-Y抗原与HLA抗原无关，而是与β2-微球蛋白有关。
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本文引用的文献
1
A STUDY OF MALIGNANT TUMOURS IN NIGERIA BY SHORT-TERM TISSUE CULTURE.尼日利亚恶性肿瘤的短期组织培养研究
J Clin Pathol. 1965 May;18(3):261-73. doi: 10.1136/jcp.18.3.261.
2
SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.体外成纤维细胞交配产生的杂种及其假定重组体的选择
Science. 1964 Aug 14;145(3633):709-10. doi: 10.1126/science.145.3633.709.
3
Sex-linked rejection of normal and neoplastic tissue. I. Distribution and specificity.正常组织和肿瘤组织的性连锁排斥反应。I. 分布与特异性
J Natl Cancer Inst. 1958 Mar;20(3):563-75.
4
Apparent Hela cell contamination of human heteroploid cell lines.人类异倍体细胞系中明显的海拉细胞污染。
Nature. 1968 Feb 24;217(5130):750-1. doi: 10.1038/217750a0.
5
Serological demonstration of H-Y (male) antigen on mouse sperm.小鼠精子上H-Y（雄性）抗原的血清学证明。
Nature. 1971 Aug 13;232(5311):478-80. doi: 10.1038/232478a0.
6
Genetic background and expressivity of histocompatibility genes.组织相容性基因的遗传背景与表达性
Science. 1967 Oct 6;158(3797):118-9. doi: 10.1126/science.158.3797.118.
7
Histocompatibility antigen in the heterogametic sex in the chicken.
Transplantation. 1967 Jul;5(4):699-706. doi: 10.1097/00007890-196707000-00012.
8
Similar location of an early embryonic antigen on mouse and human spermatozoa.小鼠和人类精子上早期胚胎抗原的相似定位。
Dev Biol. 1974 Dec;41(2):331-7. doi: 10.1016/0012-1606(74)90310-8.
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