人β2-微球蛋白与源自HL-A抗原分子的共同部分片段的多种共同特性。
Multiple common properties of human beta2-microglobulin and the common portion fragment derived from HL-A antigen molecules.
作者信息
Nakamuro K, Tanigaki N, Pressman D
出版信息
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2863-5. doi: 10.1073/pnas.70.10.2863.
Abstract
11,000-Dalton common portion fragments derived from HL-A antigen molecules were isolated and found to have a significantly high homology to beta(2)-microglobulin in amino-acid composition. Common portion fragments are also very similar to beta(2)-microglobulin with respect to molecular size, charge, and distribution in tissues. Moreover, both are found in the spent culture media of human cell lines and in human plasma and urine. Thus it appears that beta(2)-microglobulin may well be the same substance as the common portion fragment of HL-A antigen molecules.
摘要
从HL - A抗原分子衍生而来的11,000道尔顿共同部分片段被分离出来，并且发现在氨基酸组成上与β2 - 微球蛋白具有显著的高度同源性。共同部分片段在分子大小、电荷以及组织分布方面也与β2 - 微球蛋白非常相似。此外，二者都存在于人类细胞系的用过的培养基以及人类血浆和尿液中。因此，β2 - 微球蛋白很可能与HL - A抗原分子的共同部分片段是同一种物质。
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