Bell R G, Hazell L A, Price P
Clin Exp Immunol. 1976 Nov;26(2):314-26.
Weanling mice fed a 4 percent diet showed a generalized loss of lymphoid tissue which was greater than the loss of total body weight. This effect was greatest in the thymus greater than spleen greater than mesenteric lymph node. Cell loss was most pronounced during the 1st week on diets, then remained at stable levels for 3 weeks and showed a gradual rise thereafter. The effect was shown to be mediated partly by a cessation of growth in lymphoid organs due to the low protein intake and, secondly, an adrenal corticosteroid induced lympholysis which actually reduced cell numbers. Recirculating T cells and resident B cells were amongst the least affected cells whereas stem cells, non-migratory T cells and other reticuloendothelial cells were most depressed in numbers. At no stage was the germinal centre forming capacity of the mesenteric node lost although cell recruitment to antigenically stimulated nodes was diminished. During nutritional repletion the spleen, thymus and mesenteric node all showed different and characteristic regrowth. The spleen was most active initially and rapidly reconstituted haemopoietic cells and B cells. This was followed by the thymus which showed a delayed reinitiation of its normal growth kinetics which had been interrupted by the diet. The evidence suggested that full rehabilitation of the immune apparatus took place even after 2 months of nutritional deprivation.
喂食4%饮食的断奶小鼠出现了全身淋巴组织的减少，这种减少大于总体重的减轻。这种影响在胸腺中最为明显，其次是脾脏，然后是肠系膜淋巴结。细胞损失在饮食的第1周最为明显，然后在3周内保持稳定水平，此后逐渐上升。研究表明，这种影响部分是由于低蛋白摄入导致淋巴器官生长停止，其次是肾上腺皮质类固醇诱导的淋巴细胞溶解，这实际上减少了细胞数量。循环T细胞和驻留B细胞是受影响最小的细胞，而干细胞、非迁移性T细胞和其他网状内皮细胞数量减少最为明显。肠系膜淋巴结的生发中心形成能力在任何阶段都没有丧失，尽管抗原刺激淋巴结的细胞募集减少。在营养补充期间，脾脏、胸腺和肠系膜淋巴结都表现出不同的特征性再生。脾脏最初最活跃，迅速重建造血细胞和B细胞。随后是胸腺，它显示出正常生长动力学的延迟重新启动，而这种生长动力学被饮食中断。证据表明，即使经过2个月的营养剥夺，免疫器官也能完全恢复。
