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1
Preliminary studies on the synthesis of alpha2-macroglobulin by human lymphocytes in vitro.人淋巴细胞体外合成α2-巨球蛋白的初步研究。
Clin Exp Immunol. 1974 Aug;17(4):697-701.
2
Cultured human monocytes synthesize and secrete alpha2-macroglobulin.培养的人单核细胞合成并分泌α2-巨球蛋白。
J Exp Med. 1977 Jun 1;145(6):1580-9. doi: 10.1084/jem.145.6.1580.
3
The acute-phase induction of alpha 2-macroglobulin in rat hepatocyte primary cultures: action of a hepatocyte-stimulating factor, triiodothyronine and dexamethasone.大鼠肝细胞原代培养中α2-巨球蛋白的急性期诱导：肝细胞刺激因子、三碘甲状腺原氨酸和地塞米松的作用
Eur J Cell Biol. 1986 Mar;40(1):86-93.
4
[Kallikrein inhibition of the expression of the lymphocyte E rosette receptor. Prevention of this effect by alpha-2-macroglobulin].
C R Acad Sci III. 1985;301(15):675-7.
5
Determination of the synthesis and uptake of alpha 2-macroglobulin by cultured human glioma cells.培养的人胶质瘤细胞对α2-巨球蛋白合成与摄取的测定
Neoplasma. 1994;41(1):3-7.
6
Studies on the immunosuppressive properties of a pregnancy-associated alpha-macroglobulin.妊娠相关α-巨球蛋白免疫抑制特性的研究
Clin Exp Immunol. 1976 Aug;25(2):199-206.
7
An alpha2-macroglobulin associated factor produced by T lymphocytes which provides polyclonal stimulation of B lymphocytes to maintain the turnover of their surface Ig.一种由T淋巴细胞产生的α2-巨球蛋白相关因子，它能对B淋巴细胞提供多克隆刺激，以维持其表面免疫球蛋白的更新。
Immunology. 1981 Dec;44(4):745-54.
8
Rat hepatic stellate cell expression of alpha2-macroglobulin is a feature of cellular activation: implications for matrix remodelling in hepatic fibrosis.大鼠肝星状细胞中α2-巨球蛋白的表达是细胞活化的一个特征：对肝纤维化中基质重塑的影响。
Clin Sci (Lond). 1998 Aug;95(2):179-86.
9
Effect of alpha 2-macroglobulin on the lymphocyte response.α2-巨球蛋白对淋巴细胞反应的影响。
Immunology. 1982 Oct;47(2):351-6.
10
Association of macrophage-activation factor from a human cultured lymphoid cell line with albumin and alpha2-macroglobulin.来自人培养淋巴细胞系的巨噬细胞激活因子与白蛋白及α2-巨球蛋白的关联
Clin Immunol Immunopathol. 1976 Jan;5(1):91-104. doi: 10.1016/0090-1229(76)90153-7.

引用本文的文献

1
Proteomic study on the lymphocytes from pregnant Wistar rat females treated with immunosuppressive regimen.免疫抑制方案处理的怀孕 Wistar 大鼠雌性淋巴细胞的蛋白质组学研究。
Clin Transl Sci. 2023 Jan;16(1):118-127. doi: 10.1111/cts.13432. Epub 2022 Nov 10.
2
An alpha2-macroglobulin associated factor produced by T lymphocytes which provides polyclonal stimulation of B lymphocytes to maintain the turnover of their surface Ig.一种由T淋巴细胞产生的α2-巨球蛋白相关因子，它能对B淋巴细胞提供多克隆刺激，以维持其表面免疫球蛋白的更新。
Immunology. 1981 Dec;44(4):745-54.
3
Serum-free culture of hamster lymphoid cells and differential inhibition of lipopolysaccharide stimulation by isologous serum.仓鼠淋巴细胞的无血清培养及同种血清对脂多糖刺激的差异抑制作用
Infect Immun. 1976 Aug;14(2):463-70. doi: 10.1128/iai.14.2.463-470.1976.
4
Modifications of serum glycoproteins the days following a prolonged physical exercise and the influence of physical training.
Eur J Appl Physiol Occup Physiol. 1977 Dec 22;37(4):243-54. doi: 10.1007/BF00430954.
5
Synthesis and secretion of alpha-2-macroglobulin by cultured adherent lung cells. Comparison with cell strains derived from other tissues.培养的贴壁肺细胞合成与分泌α-2-巨球蛋白。与源自其他组织的细胞系比较。
J Clin Invest. 1977 Nov;60(5):1036-45. doi: 10.1172/JCI108854.
6
Cultured human monocytes synthesize and secrete alpha2-macroglobulin.培养的人单核细胞合成并分泌α2-巨球蛋白。
J Exp Med. 1977 Jun 1;145(6):1580-9. doi: 10.1084/jem.145.6.1580.
7
The association of alpha2-macroglobulin with lymphocyte membranes in chronic lymphocytic leukaemia and other disorders.α2-巨球蛋白与慢性淋巴细胞白血病及其他疾病中淋巴细胞膜的关联。
Clin Exp Immunol. 1975 Feb;19(2):237-49.

本文引用的文献

1
Characteristics of Endotoxin-Altering Fractions Derived from Normal Serum III. Isolation and Properties of Horse Serum alpha(2)-Macroglobulin.正常血清 III 衍生的内毒素改变片段的特征。马血清α(2)-巨球蛋白的分离和性质。
Infect Immun. 1970 May;1(5):431-9. doi: 10.1128/iai.1.5.431-439.1970.
2
Sites of synthesis of serum proteins. 3. Production of beta-1-C, beta-1-E and transferrin by primate and rodent cell lines.血清蛋白的合成部位。3. 灵长类和啮齿类动物细胞系产生β-1-C、β-1-E和转铁蛋白的情况。
J Immunol. 1967 Oct;99(4):660-8.
3
Purification and properties of a lymphocyte inhibition factor from human serum.人血清中淋巴细胞抑制因子的纯化及性质
Clin Exp Immunol. 1973 Oct;15(2):169-79.
4
Rapid preparation of lymphocytes for tissue-typing.用于组织分型的淋巴细胞的快速制备。
Lancet. 1969 Aug 9;2(7615):327. doi: 10.1016/s0140-6736(69)90096-8.
5
The formation of immunoglobulins by human tissues in vitro. IV. Circulating lymphocytes in normal and pathological conditions.人体组织在体外形成免疫球蛋白。IV. 正常和病理状态下的循环淋巴细胞。
Immunology. 1966 Jul;11(1):29-40.
6
A kinetic and quantitative analysis of antibody and protein synthesis during the primary response to keyhole limpet haemocyanin.对钥孔戚血蓝蛋白初次免疫应答过程中抗体和蛋白质合成的动力学及定量分析。
Immunology. 1971 Jun;20(6):1041-53.

人淋巴细胞体外合成α2-巨球蛋白的初步研究。

Preliminary studies on the synthesis of alpha2-macroglobulin by human lymphocytes in vitro.

作者信息

Tunstall A M, James K

出版信息

Clin Exp Immunol. 1974 Aug;17(4):697-701.

PMID:4143252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1554095/
Abstract

Immunoprecipitation studies with antisera to alpha-macroglobulin (αM) were undertaken on the supernatants and extracts of human peripheral blood lymphocytes cultured in serum free medium containing [C]glutamine. These studies revealed that an appreciable amount of the [C]glutamine was recovered in the αM precipitate, suggesting that this protein was synthesized by lymphocytes.

摘要

利用抗α-巨球蛋白（αM）抗血清对在含有[C]谷氨酰胺的无血清培养基中培养的人外周血淋巴细胞的上清液和提取物进行了免疫沉淀研究。这些研究表明，在αM沉淀物中回收了相当数量的[C]谷氨酰胺，这表明这种蛋白质是由淋巴细胞合成的。