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[1972 - 1977年期间伯尔尼州淋球菌对青霉素G的敏感性。耐青霉素菌株的分离]

[Sensitivity of gonococcus to penicillin G in the canton Berne during the years 1972-1977. Isolation of penicillin-resistant strains].

作者信息

Novak A

出版信息

Schweiz Med Wochenschr. 1978 Jan 21;108(3):98-101.

PMID:414353
Abstract

Since January 1972 Neisseria gonorrhoeae has been systematically investigated by culture techniques at the Institute for Hygiene and Medical Microbiology of the University of Berne. From January 1st 1972 to September 30th 1977, 820 strains were isolated. A survey of the sensitivity of gonococci to penicillin G is presented. We found three groups: 1. 700 sensitive strains (85.4%), 2. 118 strains with decreased sensitivity (14,4%), 3.2 resistant strains (0.2%). The two penicillin-resistant strains are described. Only the patients infected with gonococci of the third group were untreatable with penicillin. In view of the present epidemiological situation penicillin remains the drug of choice. However, bacteriological examination including sensitivity tests is urgently recommended and is absolutely indicated in the event of treatment failures. In addition, culture is necessary to rule out gonorrhea because the asymptomatic form is observed with increasing frequency not only in female patients but recently also in male patients.

摘要

自1972年1月起,伯尔尼大学卫生与医学微生物研究所就一直运用培养技术对淋病奈瑟菌进行系统研究。从1972年1月1日至1977年9月30日,共分离出820株菌株。本文呈现了对淋球菌对青霉素G敏感性的调查结果。我们发现了三组情况:1. 700株敏感菌株(85.4%),2. 118株敏感性降低的菌株(14.4%),3. 2株耐药菌株(0.2%)。对这两株青霉素耐药菌株进行了描述。只有感染了第三组淋球菌的患者无法用青霉素治疗。鉴于当前的流行病学状况,青霉素仍是首选药物。然而,强烈建议进行包括敏感性测试在内的细菌学检查,并且在治疗失败的情况下绝对有必要进行此项检查。此外,进行培养以排除淋病是必要的,因为不仅在女性患者中,而且最近在男性患者中,无症状形式的淋病出现频率越来越高。

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