Baker P J, Reed N D, Stashak P W, Amsbaugh D F, Prescott B
J Exp Med. 1973 Jun 1;137(6):1431-41. doi: 10.1084/jem.137.6.1431.
The effect of treatment with antilymphocyte serum (ALS) on the magnitude of the plaque-forming cell (PFC) response to Type III pneumococcal polysaccharide (SSS-III) was assessed in athymic nude mice and thymus-bearing littermate controls. Without ALS treatment, the PFC response was slightly higher in nude than in control mice. Treatment with ALS had no effect on the response of nude mice; however, considerable enhancement was noted in thymus-bearing controls. Such enhancement was ALS dose-dependent and demonstrable under conditions in which there was substantial inactivation of thymic-derived "helper" cells required for an antibody response to erythrocyte antigens. These findings suggest that amplifier and suppressor cells, which have been reported to regulate the magnitude of the antibody response to SSS-III, represent populations of thymic-derived cells (T cells) that are not present in nude mice. The activities of "helper" T cells and regulatory T cells appear to be independent of one another and mediated by separate subpopulations of T cells.
在无胸腺裸鼠和有胸腺的同窝对照小鼠中，评估了抗淋巴细胞血清（ALS）治疗对针对Ⅲ型肺炎球菌多糖（SSS-III）的空斑形成细胞（PFC）反应强度的影响。未经ALS治疗时，裸鼠的PFC反应略高于对照小鼠。ALS治疗对裸鼠的反应没有影响；然而，在有胸腺的对照小鼠中观察到了显著增强。这种增强是ALS剂量依赖性的，并且在对红细胞抗原产生抗体反应所需的胸腺来源的“辅助”细胞大量失活的条件下也可证明。这些发现表明，据报道可调节对SSS-III的抗体反应强度的放大细胞和抑制细胞，代表了裸鼠中不存在的胸腺来源细胞（T细胞）群体。“辅助”T细胞和调节性T细胞的活性似乎彼此独立，且由T细胞的不同亚群介导。
