Hernández A, Papadakos P J, Torres A, González D A, Vives M, Ferrando C, Baeza J
Director Anaesthesia & ICU, Grupo Policlínica, Ibiza, Islas Baleares, España.
Director Critical Care Medicine, University of Rochester, Professor Anesthesia, Surgery, Neurology, and Neurosurgery, Rochester, Nueva York, Estados Unidos.
Rev Esp Anestesiol Reanim (Engl Ed). 2020 May;67(5):245-252. doi: 10.1016/j.redar.2020.03.004. Epub 2020 Apr 14.
Pneumonia caused by coronavirus, which originated in Wuhan, China, in late 2019, has been spread around the world already becoming a pandemic. Unfortunately, there is not yet a specific vaccine or effective antiviral drug for treating COVID-19. Many of these patients deteriorate rapidly and require intubation and are mechanically ventilated, which is causing the collapse of the health system in many countries due to lack of ventilators and intensive care beds. In this document we review two simple adjuvant therapies to administer, without side effects, and low cost that could be useful for the treatment of acute severe coronavirus infection associated with acute respiratory syndrome (SARS-CoV-2). VitaminC, a potent antioxidant, has emerged as a relevant therapy due to its potential benefits when administered intravenous. The potential effect of vitaminC in reducing inflammation in the lungs could play a key role in lung injury caused by coronavirus infection. Another potential effective therapy is ozone: it has been extensively studied and used for many years and its effectiveness has been demonstrated so far in multiples studies. Nevertheless, our goal is not to make an exhaustive review of these therapies but spread the beneficial effects themselves. Obviously clinical trials are necessaries, but due to the potential benefit of these two therapies we highly recommended to add to the therapeutic arsenal.
2019年末起源于中国武汉的冠状病毒引起的肺炎已在全球传播，成为大流行病。不幸的是，目前尚无用于治疗新冠病毒病（COVID-19）的特异性疫苗或有效的抗病毒药物。许多此类患者病情迅速恶化，需要插管并进行机械通气，由于呼吸机和重症监护床位短缺，这正在导致许多国家的卫生系统崩溃。在本文件中，我们回顾了两种简单的辅助治疗方法，它们无副作用且成本低廉，可能有助于治疗与急性呼吸综合征相关的急性重症冠状病毒感染（SARS-CoV-2）。维生素C是一种有效的抗氧化剂，由于静脉给药时具有潜在益处，已成为一种相关治疗方法。维生素C在减轻肺部炎症方面的潜在作用可能在冠状病毒感染引起的肺损伤中起关键作用。另一种潜在有效的治疗方法是臭氧：它已被广泛研究和使用多年，目前在多项研究中已证明其有效性。然而，我们的目标不是对这些治疗方法进行详尽的综述，而是传播它们本身的有益效果。显然临床试验是必要的，但由于这两种治疗方法的潜在益处，我们强烈建议将其纳入治疗手段。
