硝呋替莫诱导豚鼠对结核菌素纯蛋白衍生物（PPD）的细胞介导免疫反应改变。
Nifurtimox-induced alterations in the cell-mediated immune response to PPD tin guinea-pigs.
作者信息
Lelchuk R, Cardoni R L, Levis S
出版信息
Clin Exp Immunol. 1977 Dec;30(3):469-73.
Positive skin reactions to PPD in guinea-pigs immunized with Freund's complete adjuvant (FCA) were reversed after treatment with 10 mg/kg/day nifurtimox for 12 days. The in vitro migration of peripheral blood leucocytes from FCA-immunized guinea-pigs was inhibited with PPD, but it returned to normal values after nifurtimox treatment. Furthermore, the cell-free supernatant from PPD-stimulated lymphocytes from FCA-immunized nifurtimox-treated guinea-pigs did not inhibit the migration of normal cells. Thus the administration of nifurtimox impaired the specific cell-mediated immune response to PPD both in vivo and in vitro.
用弗氏完全佐剂（FCA）免疫的豚鼠对结核菌素纯蛋白衍生物（PPD）产生的阳性皮肤反应，在以10毫克/千克/天的硝呋替莫治疗12天后得到逆转。来自FCA免疫豚鼠的外周血白细胞的体外迁移受到PPD抑制，但在硝呋替莫治疗后恢复到正常值。此外，来自FCA免疫且经硝呋替莫治疗的豚鼠的PPD刺激淋巴细胞的无细胞上清液不抑制正常细胞的迁移。因此，硝呋替莫的给药在体内和体外均损害了对PPD的特异性细胞介导免疫反应。
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