Yik K Y, Dreidger A A, Watson W C
Dig Dis Sci. 1982 Nov;27(11):972-5. doi: 10.1007/BF01391741.
A double-blind study was performed to determine the effect of prostaglandin E2 (PGE2) tablets on aspirin-induced blood loss in 20 healthy male volunteers. All subjects took aspirin, and 9 in the control group and 11 in the treatment group received placebo and PGE2 respectively. One tablet of PGE2, 0.5 mg, was given four times daily for five days. Two tablets of unbuffered aspirin (640 mg) were given four times daily for four days commencing one day after the start of the PGE2 or placebo. Fecal blood loss was measured using 51Cr-labeled red cells. There was no significant difference in serum salicylate levels. There was a significant increase in fecal blood loss in control subjects on the third and fourth days on aspirin and for 4 days following aspirin ingestion. In the treatment group, fecal blood loss was prevented by PGE2.
进行了一项双盲研究，以确定前列腺素E2（PGE2）片剂对20名健康男性志愿者阿司匹林诱导的失血的影响。所有受试者均服用阿司匹林，对照组9人，治疗组11人，分别接受安慰剂和PGE2。每天服用4次0.5毫克的PGE2片剂，持续5天。从开始服用PGE2或安慰剂一天后开始，每天服用4次两片无缓冲阿司匹林（640毫克），持续4天。使用51Cr标记的红细胞测量粪便失血量。血清水杨酸盐水平无显著差异。对照组受试者在服用阿司匹林的第三天和第四天以及服用阿司匹林后的4天内，粪便失血量显著增加。在治疗组中，PGE2可防止粪便失血。
