通过放射性苯胺清除率与氨基比林清除率比较来测量犬胃黏膜血流量。
The measurement of dog gastric mucosal blood flow by radioactive aniline clearance compared with amidopyrine clearance.
作者信息
Curwain B P, Holton P
出版信息
J Physiol. 1973 Feb;229(1):115-31. doi: 10.1113/jphysiol.1973.sp010130.
Abstract
- Methods for the estimation of radioactive aniline in body fluids are described. The recovery of aniline added to blood, plasma and gastric juice was over 90% of the recovery from saline.2. In the doses used aniline caused methaemoglobinaemia of 5-11% of total haemoglobin. No other effect was detected. Gastric secretion was also unaffected.3. Aniline clearance increased in parallel with acid secretion from Heidenhain pouches in conscious dogs and in anaesthetized dogs. In conscious dogs the ratio of aniline clearance to acid secretion was significantly higher for histamine stimulation than for pentagastrin stimulation.4. Aniline and amidopyrine clearances were compared simultaneously in the same dogs. Aniline clearance was about 80% of amidopyrine clearance.5. The proportion of aniline bound to plasma proteins was measured by two methods and found to be 25%. When aniline clearance was corrected for plasma binding, aniline and amidopyrine clearances were equal.
摘要
本文描述了体液中放射性苯胺的估算方法。添加到血液、血浆和胃液中的苯胺回收率超过了从盐溶液中回收量的90%。
在所使用的剂量下，苯胺导致高铁血红蛋白血症，占总血红蛋白的5 - 11%。未检测到其他影响。胃液分泌也未受影响。
在清醒犬和麻醉犬中，苯胺清除率与海登海因小胃的酸分泌平行增加。在清醒犬中，组胺刺激下苯胺清除率与酸分泌的比值显著高于五肽胃泌素刺激下的比值。
在同一只犬中同时比较苯胺和氨基比林的清除率。苯胺清除率约为氨基比林清除率的80%。
通过两种方法测量了与血浆蛋白结合的苯胺比例，发现为25%。当校正血浆结合对苯胺清除率的影响后，苯胺和氨基比林的清除率相等。
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The measurement of dog gastric mucosal blood flow by radioactive aniline clearance compared with amidopyrine clearance.通过放射性苯胺清除率与氨基比林清除率比较来测量犬胃黏膜血流量。
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