Houghton G W, Richens A
J Neurol Neurosurg Psychiatry. 1974 Mar;37(3):275-81. doi: 10.1136/jnnp.37.3.275.
Routine estimation of serum phenytoin levels in patients newly admitted to a Special Centre for Epilepsy showed that 40% of those receiving sulthiame in addition to phenytoin had levels in the toxic range. Four long-stay patients became drug intoxicated when sulthiame treatment was started. Sulthiame appears to inhibit the hepatic hydroxylation of phenytoin.
对新入住一家癫痫专科医院的患者进行血清苯妥英水平的常规评估发现，那些除苯妥英外还接受舒噻美治疗的患者中有40%的苯妥英水平处于中毒范围。4名长期住院患者在开始舒噻美治疗后出现药物中毒。舒噻美似乎会抑制苯妥英的肝脏羟化作用。
